Genetic Analysis of the Measles Virus From the Outbreaks in South Korea, 2019

被引：5

作者：

Kim, Jeong-Min ^{[1
]}

Park, Sehee ^{[2
]}

Kim, Sujin ^{[3
]}

Park, Kye Ryeong ^{[3
]}

Wang, Jin-Sook ^{[3
]}

Chung, Yoon-Seok ^{[4
]}

机构：

[1] Korea Dis Control & Prevent Agcy, Div Emerging Infect Dis, Bur Infect Dis Diag Control, Cheongju, South Korea

[2] Korea Dis Control & Prevent Agcy, Div Acute Viral Dis, Ctr Emerging Virus Res, Cheongju, South Korea

[3] Korea Dis Control & Prevent Agcy, Div Viral Dis, Bur Infect Dis Diag Control, Cheongju, South Korea

[4] Korea Dis Control & Prevent Agcy, Div Infect Dis Diag Control, Honam Reg Ctr Dis Control & Prevent, Gwangju Si, South Korea

来源：

FRONTIERS IN MICROBIOLOGY | 2021年 / 12卷

关键词：

measles viruses; epidemiology; N-450; reverse transcription-polymerase chain reaction; MF-NCR-H; REPUBLIC-OF-KOREA; VACCINATION; TRANSMISSION; GENOTYPES;

D O I：

10.3389/fmicb.2021.763107

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Three genotypes (B3, D8, and H1) of the measles virus (MeV) have recently caused global outbreaks. In Korea, four measles outbreaks were reported during 2018-2019 and most patients were infants and health care workers in their 20s and 30s. To investigate the genetic characteristics and molecular epidemiology of the outbreaks, we analyzed the sequence of MeVs by targeting the N-450, MF-NCR, and/or H gene regions. Considering their phylogenetic relationships, besides the N-450 and MF-NCR sequences that are commonly used for genotyping MeVs, the MF-NCR-H sequence was related to the dynamics for identifying the transmission of MeVs. Phylogenetic clustering patterns reconstructed from the MF-NCR-H sequence set revealed that genotype D8 caused three of the four outbreaks, while B3 seemed to have induced the fourth outbreak. These results suggest that the MF-NCR-H sequence is useful for rapid confirmation of measles outbreaks and to identify the epidemiological routes of MeVs.

引用

页数：10

共 18 条

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[2]

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