SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations

被引：38

作者：

Yang, Wan-Ting ^{[1
]}

Huane, Wei-Hsuan ^{[1
]}

Liao, Tsai-Ling ^{[2
]}

Hsiao, Tzu-Hung ^{[2
]}

Chuang, Han-Ni ^{[2
]}

Liu, Po-Yu ^{[1
,3
,4
]}

机构：

[1] Taichung Vet Gen Hosp, Dept Internal Med, Div Infect, 1650 Taiwan Blvd Sect 4, Taichung 4070, Taiwan

[2] Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan

[3] Natl Chung Hsing Univ, PhD Program Translat Med, Taichung, Taiwan

[4] Natl Chung Hsing Univ, Rong Hsing Res Ctr Translat Med, Taichung, Taiwan

来源：

INFECTION AND DRUG RESISTANCE | 2022年 / 15卷

关键词：

E484K; SARS-CoV-2; variant; coronavirus spike glycoprotein; SARS-CoV-2 convalescent sera treatment; monoclonal antibody; vaccine; RECEPTOR-BINDING DOMAIN; PROTEIN;

D O I：

10.2147/IDR.S344099

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly over the world and claimed million lives. The virus evolves constantly, and a swarm of mutants is a now major concern globally. Distinct variants could have independently converged on same mutation, despite being detected in different geographic regions, which suggested it could confer an evolutionary advantage. E484K has rapidly emerged and has frequently been detected in several SARS-CoV-2 variants of concern. In this study, we review the epidemiology and impact of E484K, its effects on neutralizing effect of several monoclonal antibodies, convalescent plasma, and post-vaccine sera.

引用

页码：373 / 385

页数：13

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