The INK4a/ARF network in tumour suppression

被引：774

作者：

Sherr, CJ ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Howard Hughes Med Inst, Dept Tumor Cell Biol, Memphis, TN 38105 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 10期

关键词：

D O I：

10.1038/35096061

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.

引用

页码：731 / 737

页数：7

共 77 条

[1] p14ARF links the tumour suppressors RB and p53 [J].

Bates, S ;

Phillips, AC ;

Clark, PA ;

Stott, F ;

Peters, G ;

Ludwig, RL ;

Vousden, KH .

NATURE, 1998, 395 (6698) :124-125

[2] Mechanisms of p53-mediated apoptosis [J].

Bates, S ;

Vousden, KH .

CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (01) :28-37

[3] Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation [J].

Brenner, AJ ;

Stampfer, MR ;

Aldaz, CM .

ONCOGENE, 1998, 17 (02) :199-205

[4] p16INK4A and p19ARF act in overlapping pathways in cellular immortalization [J].

Carnero, A ;

Hudson, JD ;

Price, CM ;

Beach, DH .

NATURE CELL BIOLOGY, 2000, 2 (03) :148-155

[5] Cooperative effects of INK4a and ras in melanoma susceptibility in vivo [J].

Chin, L ;

Pomerantz, J ;

Polsky, D ;

Jacobson, M ;

Cohen, C ;

CordonCardo, C ;

Horner, JW ;

DePinho, RA .

GENES & DEVELOPMENT, 1997, 11 (21) :2822-2834

[6] Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions [J].

Dannenberg, JH ;

van Rossum, A ;

Schuijff, L ;

Riele, HT .

GENES & DEVELOPMENT, 2000, 14 (23) :3051-3064

[7] E1A signaling to p53 involves the p19ARF tumor suppressor [J].

de Stanchina, E ;

McCurrach, ME ;

Zindy, F ;

Shieh, SY ;

Ferbeyre, G ;

Samuelson, AV ;

Prives, C ;

Roussel, MF ;

Sherr, CJ ;

Lowe, SW .

GENES & DEVELOPMENT, 1998, 12 (15) :2434-2442

[8] Distinct roles for E2F proteins in cell growth control and apoptosis [J].

DeGregori, J ;

Leone, G ;

Miron, A ;

Jakoi, L ;

Nevins, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (14) :7245-7250

[9] The regulation of E2F by pRB-family proteins [J].

Dyson, N .

GENES & DEVELOPMENT, 1998, 12 (15) :2245-2262

[10] Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis [J].

Eischen, CM ;

Weber, JD ;

Roussel, MF ;

Sherr, CJ ;

Cleveland, JL .

GENES & DEVELOPMENT, 1999, 13 (20) :2658-2669

← 1 2 3 4 5 6 7 8 →