CAR T cell therapy: inroads to response and resistance

被引：156

作者：

Brown, Christine E. ^{[1
]}

Mackall, Crystal L. ^{[2
]}

机构：

[1] City Hope Natl Med Ctr, Immunotherapy, Duarte, CA 91010 USA

[2] Stanford Univ, Pediat & Med, Stanford, CA 94305 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2019年 / 19卷 / 02期

关键词：

D O I：

10.1038/s41577-018-0119-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Here, we highlight key papers published in 2018 that advance our understanding of resistance to chimeric antigen receptor (CAR) T cell immunotherapy for leukaemia and lymphoma and in so doing reveal barriers that must be addressed to increase efficacy of this novel class of therapeutics for B cell malignancies and expand their reach to solid tumours.

引用

页码：73 / 74

页数：2

共 10 条

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