Costunolide: A novel anti-cancer sesquiterpene lactone

被引：37
作者：
Rasul, Azhar [1 ]
Parveen, Saima [2 ]
Ma, Tonghui [1 ]
机构：
[1] Jilin Univ, Bethune Hosp 2, Cent Res Lab, Changchun 130041, Peoples R China
[2] Islamia Univ Bahawalpur, Fac Sci, Dept Chem, Bahawalpur 63100, Pakistan
来源：
BANGLADESH JOURNAL OF PHARMACOLOGY | 2012年 / 7卷 / 01期
关键词：
Anticancer; Apoptosis; Costunolide; Sesquiterpene lactones; NF-KAPPA-B; APOPTOTIC CHROMATIN CONDENSATION; INDUCE CELL-DEATH; SAUSSUREA-LAPPA; LAURUS-NOBILIS; NATURAL-PRODUCTS; STEM BARK; TELOMERASE ACTIVITY; LEUKEMIA-CELLS; CANCER CELLS;
D O I：
10.3329/bjp.v7i1.10066
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Currently an ample interest is found among oncologists to explore anticancer compounds from herbs. Sesquiterpene lactones have accredited significant attention in pharmacological research. Costunolide is a well-known sesquiterpene lactone present in plants used as popular herbal remedy. Several plant-derived compounds are currently successfully employed in cancer treatment. Growing evidences demonstrated that costunolide possesses anticancer activities by inhibiting cell proliferation, tumor invasion, angiogenesis, metastasis and inducing apoptosis of a variety of tumor cell lines. This review is aimed to summarize the recent researches about costunolide focusing on anti-tumor activity and to lay emphasis on its molecular targets and its mechanisms, which may help the further design and conduct of preclinical and clinical trials.
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收藏
页码：6 / 13
页数：8
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