A prospective study of grey matter and cognitive function alterations in chemotherapy-treated breast cancer patients

被引：77
作者：
Lepage, Chris [1 ]
Smith, Andra M. [1 ]
Moreau, Jeremy [1 ]
Barlow-Krelina, Emily [1 ]
Wallis, Nancy [1 ]
Collins, Barbara [1 ,2 ]
MacKenzie, Joyce [2 ]
Scherling, Carole [3 ]
机构：
[1] Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada
[2] Ottawa Hosp, Ottawa, ON K1Y 4E9, Canada
[3] UCSF, Sandler Neurosci Ctr, Memory & Aging Ctr, Neurol, San Francisco, CA 94158 USA
来源：
SPRINGERPLUS | 2014年 / 3卷
关键词：
Breast cancer; Voxel-based morphometry; Chemotherapy; Cognition; MRI; Neuroimaging; ADJUVANT CHEMOTHERAPY; SYSTEMIC CHEMOTHERAPY; ORBITOFRONTAL CORTEX; RESPONSE-INHIBITION; HIPPOCAMPAL VOLUME; BRAIN STRUCTURE; WORKING-MEMORY; SURVIVORS; WOMEN; METAANALYSIS;
D O I：
10.1186/2193-1801-3-444
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Purpose: Subsequent to chemotherapy treatment, breast cancer patients often report a decline in cognitive functioning that can adversely impact many aspects of their lives. Evidence has mounted in recent years indicating that a portion of breast cancer survivors who have undergone chemotherapy display reduced performance on objective measures of cognitive functioning relative to comparison groups. Neurophysiological support for chemotherapy-related cognitive impairment has been accumulating due to an increase in neuroimaging studies in this field; however, longitudinal studies are limited and have not examined the relationship between structural grey matter alterations and neuropsychological performance. The aim of this study was to extend the cancer-cognition literature by investigating the association between grey matter attenuation and objectively measured cognitive functioning in chemotherapy-treated breast cancer patients. Methods: Female breast cancer patients (n = 19) underwent magnetic resonance imaging after surgery but before commencing chemotherapy, one month following treatment, and one year after treatment completion. Individually matched controls (n = 19) underwent imaging at similar intervals. All participants underwent a comprehensive neuropsychological battery comprising four cognitive domains at these same time points. Longitudinal grey matter changes were investigated using voxel-based morphometry. Results: One month following chemotherapy, patients had distributed grey matter volume reductions. One year after treatment, a partial recovery was observed with alterations persisting predominantly in frontal and temporal regions. This course was not observed in the healthy comparison group. Processing speed followed a similar trajectory within the patient group, with poorest scores obtained one month following treatment and some improvement evident one year post-treatment. Conclusion: This study provides further credence to patient claims of altered cognitive functioning subsequent to chemotherapy treatment.
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页数：10
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