Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome-related colonic hypersensitivity

被引：17

作者：

Asano, Teita

Tanaka, Ken-ichiro ^{[2
]}

Suemasu, Shintaro

Ishihara, Tomoaki

Tahara, Kayoko

Suzuki, Toshio ^{[3
]}

Suzuki, Hidekazu ^{[4
]}

Fukudo, Shin ^{[5
]}

Mizushima, Tohru ^{[1
,2
]}

机构：

[1] Keio Univ, Dept Analyt Chem, Fac Pharm, Minato Ku, Tokyo 1058512, Japan

[2] Kumamoto Univ, Grad Sch Med & Pharmaceut Sci, Kumamoto 8620973, Japan

[3] Daiso Co Ltd, Res & Dev, Amagasaki, Hyogo 6600842, Japan

[4] Keio Univ, Div Gastroenterol & Hepatol, Dept Internal Med, Sch Med, Tokyo 1608582, Japan

[5] Tohoku Univ, Dept Behav Med, Grad Sch Med, Sendai, Miyagi 9808575, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 420卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

Irritable bowel syndrome; Fecal pellet output; Visceral pain response; beta-Glucan; BETA-GLUCAN; CYTOKINE RELEASE; MODEL; ANTAGONIST; STRAIN; MICE; INFLAMMATION; SENSITIVITY; DISTENSION; STRESS;

D O I：

10.1016/j.bbrc.2012.03.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain associated with altered bowel habits. Since the prevalence of IBS is very high and thus, involves elevated health-care costs, treatment of this condition by methods other than prescribed medicines could be beneficial. beta-(1,3)-D-glucan with beta-(1.6) branches (beta-glucan) has been used as a nutritional supplement for many years. In this study, we examined the effect of beta-glucan on fecal pellet output and visceral pain response in animal models of IBS. Oral administration of beta-glucan suppressed the restraint stress- or drug-induced fecal pellet output. beta-Glucan also suppressed the visceral pain response to colorectal distension. These results suggest that beta-glucan could be beneficial for the treatment and prevention of IBS. (C) 2012 Published by Elsevier Inc.

引用

页码：444 / 449

页数：6

共 36 条

[1] Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior [J].