共 36 条
Combination Biomarkers to Diagnose Sepsis in the Critically Ill Patient
被引:236
作者:

Gibot, Sebastien
论文数: 0 引用数: 0
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机构:
Hop Cent, Serv Reanimat Med, F-54035 Nancy, France
Nancy Univ, Fac Med, Grp Choc, Contrat Avenir INSERM, Nancy, France Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Bene, Marie C.
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机构:
CHU, Immunol Lab, Vandoeuvre Les Nancy, France Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Noel, Robin
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机构:
Hop Bocage, Dijon, France Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Massin, Frederic
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h-index: 0
机构:
CHU Brabois, Immunol Lab, Vandoeuvre Les Nancy, France Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Guy, Julien
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机构:
Hop Bocage, Hematol Lab, Dijon, France Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Cravoisy, Aurelie
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机构: Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Barraud, Damien
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机构: Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Bittencourt, Marcelo De Carvalho
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h-index: 0
机构:
CHU, Immunol Lab, Vandoeuvre Les Nancy, France Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Quenot, Jean-Pierre
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h-index: 0
机构:
Hop Bocage, Dijon, France Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Bollaert, Pierre-Edouard
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h-index: 0
机构: Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Faure, Gilbert
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h-index: 0
机构:
CHU, Immunol Lab, Vandoeuvre Les Nancy, France Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Charles, Pierre-Emmanuel
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h-index: 0
机构:
Hop Bocage, Dijon, France Hop Cent, Serv Reanimat Med, F-54035 Nancy, France
机构:
[1] Hop Cent, Serv Reanimat Med, F-54035 Nancy, France
[2] Nancy Univ, Fac Med, Grp Choc, Contrat Avenir INSERM, Nancy, France
[3] CHU, Immunol Lab, Vandoeuvre Les Nancy, France
[4] Hop Bocage, Dijon, France
[5] CHU Brabois, Immunol Lab, Vandoeuvre Les Nancy, France
[6] Hop Bocage, Hematol Lab, Dijon, France
关键词:
sepsis;
diagnostic biomarkers;
procalcitonin;
CD64;
sTREM-1;
NEUTROPHIL CD64 EXPRESSION;
SOLUBLE TRIGGERING RECEPTOR;
MYELOID CELLS-1;
SERUM PROCALCITONIN;
ADULT PATIENTS;
INFECTION;
MARKERS;
ACCURACY;
PLASMA;
SCORE;
D O I:
10.1164/rccm.201201-0037OC
中图分类号:
R4 [临床医学];
学科分类号:
1002 ;
100602 ;
摘要:
Rationale: Although the outcome of sepsis benefits from the prompt administration of appropriate antibiotics on correct diagnosis, the assessment of infection in critically ill patients is often a challenge for clinicians. In this setting, simple biomarkers, especially when used in combination, could prove useful. Objectives: To determine the usefulness of combination biomarkers to diagnose sepsis. Methods: Three hundred consecutive patients were enrolled to construct a biologic score that was next validated in an independent prospective cohort of 79 critically ill patients from another center. Measurement and Main Results: Plasma concentrations of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and procalcitonin (PCT) were assayed, and the expression of the high-affinity immunoglobulin-Fc fragment receptor I (Fc gamma RI) CD64 on neutrophils (polymorphonuclear [PMN] CD64 index) in flow cytometry was measured. A "bioscore" combining these biomarkers was constructed. Serum concentrations of PCT and sTREM-1 and the PMN CD64 index were higher in patients with sepsis compared with all others (P < 0.001 for the three markers). These biomarkers were all independent predictors of infection, the best receiver-operating characteristic curve being obtained for the PMN CD64 index. The performance of the bioscore, better than that of each individual biomarker, was externally confirmed in the validation cohort. Conclusions: This prospective study, including inceptive and validation cohorts of unselected intensive care unit patients, demonstrates the high performance of a bioscore combining the PMN CD64 index together with PCT and sTREM-1 serum levels in diagnosing sepsis in the critically ill patient.
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页码:65 / 71
页数:7
相关论文
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Univ S Manchester Hosp, Dept Pathol, Manchester M20 8LR, Lancs, England Univ Manchester, Med Genet Res Grp, Manchester M13 0JH, Lancs, England

Amir, E.
论文数: 0 引用数: 0
h-index: 0
机构:
Princess Margaret Hosp, Div Med Oncol, Toronto, ON M4X 1K9, Canada Univ Manchester, Med Genet Res Grp, Manchester M13 0JH, Lancs, England

Howell, A.
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h-index: 0
机构:
Univ S Manchester Hosp, Genesis Prevent Ctr, Manchester M20 8LR, Lancs, England
Wythenshawe Hosp NHS Fdn Trust, Manchester, Lancs, England
The Christie, CRUK Dept Med Oncol, Manchester, Lancs, England Univ Manchester, Med Genet Res Grp, Manchester M13 0JH, Lancs, England
[10]
Plasma level of a triggering receptor expressed on myeloid cells-1:: Its diagnostic accuracy in patients with suspected sepsis
[J].
Gibot, S
;
Kolopp-Sarda, MN
;
Béné, MC
;
Cravoisy, A
;
Levy, B
;
Faure, GC
;
Bollaert, PE
.
ANNALS OF INTERNAL MEDICINE,
2004, 141 (01)
:9-15

Gibot, S
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机构: Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Kolopp-Sarda, MN
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h-index: 0
机构: Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Béné, MC
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h-index: 0
机构: Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Cravoisy, A
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h-index: 0
机构: Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Levy, B
论文数: 0 引用数: 0
h-index: 0
机构: Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Faure, GC
论文数: 0 引用数: 0
h-index: 0
机构: Hop Cent, Serv Reanimat Med, F-54035 Nancy, France

Bollaert, PE
论文数: 0 引用数: 0
h-index: 0
机构: Hop Cent, Serv Reanimat Med, F-54035 Nancy, France