Hospital Resource Utilization and Treatment Cost of Skeletal-Related Events in Patients with Metastatic Breast or Prostate Cancer: Estimation for the Portuguese National Health System

被引：30

作者：

Felix, J. ^{[1
]}

Andreozzi, V. ^{[2
,3
]}

Soares, M. ^{[1
]}

Borrego, P. ^{[1
]}

Gervasio, H. ^{[4
]}

Moreira, A. ^{[5
]}

Costa, L. ^{[6
]}

Marcelo, F. ^{[7
]}

Peralta, F. ^{[8
]}

Furtado, I. ^{[9
]}

Pina, F. ^{[10
]}

Albuquerque, C. ^{[11
]}

Santos, A. ^{[12
]}

Passos-Coelho, J. L. ^{[5
]}

机构：

[1] Exigo Consultores, Alhos Vedros, Portugal

[2] Univ Lisbon, Fac Ciencias, P-1200 Lisbon, Portugal

[3] Univ Lisbon, Ctr Estat Aplicacoes, P-1200 Lisbon, Portugal

[4] Inst Portugues Oncol Francisco Gentil, Coimbra, Portugal

[5] Inst Portugues Oncol Francisco Gentil, Lisbon, Portugal

[6] Hosp Santa Maria, Lisbon, Portugal

[7] Hosp Santo Antonio, Oporto, Portugal

[8] Maternidade Bissaia Barreto, Coimbra, Portugal

[9] Hosp Distrital Faro, Faro, Portugal

[10] Hosp Sao Joao, Oporto, Portugal

[11] Hosp Sao Bernardo, Setubal, Portugal

[12] Hosp Sao Marcos, Braga, Portugal

来源：

VALUE IN HEALTH | 2011年 / 14卷 / 04期

关键词：

breast cancer; costs; hospital; prostate cancer; skeletal-related events; ZOLEDRONIC ACID; BONE; COMPLICATIONS; PAMIDRONATE; BISPHOSPHONATES; CLODRONATE; MANAGEMENT; CARCINOMA; SURVIVAL; EFFICACY;

D O I：

10.1016/j.jval.2010.11.014

中图分类号：

F [经济];

学科分类号：

02 ;

摘要：

Background: Skeletal-related events (SREs) occur frequently in patients with bone metastases as a result of breast (BC) and prostate (PC) cancers. They increase both morbidity and mortality and lead to extensive health-care resource utilization. Methods: Health care resource utilization by BC/PC patients with at least one SRE during the preceding 12 months was assessed through retrospective chart review. SRE-treatment costs were estimated using the Portuguese Ministry of Health cost database and analyzed using generalized linear models. Results: This study included 152 patients from nine hospitals. The mean (SD) annual SRE-treatment cost per patient was (sic)5963 ((sic)3646) and (sic)5711 ((sic)4347), for BC (n=121) and PC (n=31) patients, respectively. Mean cost per single episode ranged between (sic)1485 (radiotherapy) and (sic)13,203 (spinal cord compression). Early onset of bone metastasis (P - 0.03) and diagnosis of bone metastases at or after the occurrence of the first SRE (P < 0.001) were associated with higher SRE-treatment costs. Conclusion: These results reveal the high hospital SRE-treatment costs, highlighting the need for early diagnosis and treatment, and identify key factors determining the economic value of therapies for patients with skeletal metastases.

引用

页码：499 / 505

页数：7

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