Emerging strategies for the early detection and prevention of head and neck squamous cell cancer

被引：18

作者：

Dasgupta, Santanu ^{[1
]}

Dash, Rupesh ^{[1
]}

Das, Swadesh K. ^{[1
]}

Sarkar, Devanand ^{[1
]}

Fisher, Paul B. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, VCU Inst Mol Med, Dept Human & Mol Genet,VCU Massey Canc Ctr, Richmond, VA 23298 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2012年 / 227卷 / 02期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; MITOCHONDRIAL-DNA MUTATIONS; HUMAN-PAPILLOMAVIRUS INFECTION; LASER-CAPTURE MICRODISSECTION; FACTOR RECEPTOR EXPRESSION; CARCINOGENESIS IN-VIVO; ORAL-CANCER; CONSTITUTIVE ACTIVATION; PHARYNGEAL CANCER; PROMOTER METHYLATION;

D O I：

10.1002/jcp.22767

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite significant improvements in therapeutic protocols, head and neck squamous cell carcinoma (HNSCC) remains a major health problem worldwide. The 5-year post-therapeutic survival rate is among the lowest of the major cancers with loco-regional relapse being the main cause of death. Moreover, in most instances, the quality of life of the afflicted patient is severely compromised. The poor prognosis for HNSCC is primarily due to disease detection at advanced stages. Accordingly, development of early detection and preventive strategies are essential. Recent advances in our understanding of the molecular biology and etiology of HNSCC should facilitate development of improved intervention and therapeutic approaches. The present review discusses the potential role of such factors for developing preventive and early diagnostic strategies for HNSCC management. J. Cell. Physiol. 227: 467473, 2012. (C) 2011 Wiley Periodicals, Inc.

引用

页码：467 / 473

页数：7

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