Biomechanical response of ascending thoracic aortic aneurysms: association with structural remodelling

被引:70
作者
Sokolis, Dimitrios P. [1 ]
Kritharis, Eleftherios P. [1 ]
Giagini, Athina T. [1 ]
Lampropoulos, Konstantinos M. [1 ]
Papadodima, Stavroula A. [2 ]
Iliopoulos, Dimitrios C. [3 ,4 ]
机构
[1] Fdn Biomed Res, Lab Biomech, Athens 11527, Greece
[2] Univ Athens, Sch Med, Dept Forens Med & Toxicol, Athens 11527, Greece
[3] Univ Athens, Sch Med, Lab Expt Surg & Surg Res, Athens 11527, Greece
[4] Athens Med Ctr, Dept Cardiothorac Surg, Athens, Greece
关键词
strain-energy function; elastin; collagen; anisotropy; heterogeneity; dissection; PASSIVE MECHANICAL-PROPERTIES; COLLAGEN ORGANIZATION; MEDIAL DEGENERATION; WALL STRESS; ROOT MOTION; BEHAVIOR; ARTERIES; TISSUE; VALVE; PATHOGENESIS;
D O I
10.1080/10255842.2010.522186
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Ascending thoracic aortic aneurysms (ATAA) were resected from patients during graft replacement and non-aneurysmal vessels during autopsy. Tissues were histomechanically tested according to region and orientation, and the experimental recordings reduced with a Fung-type strain-energy function, affording faithful biomechanical characterisation of the vessel response. The material and rupture properties disclosed that ATAA and non-aneurysmal aorta were stiffer and stronger circumferentially, accounted by preferential collagen reinforcement. The deviation of microstructure in the right lateral region, with a longitudinal extracellular matrix and smooth muscle element sub-intimally, reflects the regional differences in material properties identified. ATAA had no effect on strength, but caused stiffening and extensibility reduction, corroborating our histological observation of deficient elastin but not collagen content. Our findings may serve as input data for the implementation of finite element models, to be used as improved surgical intervention criteria, and may further our understanding of the pathophysiology of ATAA and aortic dissection.
引用
收藏
页码:231 / 248
页数:18
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