Bacterial Reductionism: Host Thiols Enhance Virulence

被引：1

作者：

Sperandio, Vanessa ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

来源：

CELL HOST & MICROBE | 2015年 / 18卷 / 01期

关键词：

BURKHOLDERIA-PSEUDOMALLEI; INTRACELLULAR PATHOGEN; GLUTATHIONE; SYSTEM;

D O I：

10.1016/j.chom.2015.06.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Intracellular bacteria exploit host cytosolic signals to upregulate virulence genes. In this issue of Cell Host & Microbe, Wong et al. (2015) show that Burkholderia pseudomallei senses host cytosolic glutathione, a low-molecular-weight thiol, through the membrane-bound histidine sensor kinase VirA, highlighting the importance of inter-kingdom signaling in bacterial pathogenesis.

引用

页码：7 / 8

页数：2