Bacterial Reductionism: Host Thiols Enhance Virulence

被引：1

作者：

Sperandio, Vanessa ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

来源：

CELL HOST & MICROBE | 2015年 / 18卷 / 01期

关键词：

BURKHOLDERIA-PSEUDOMALLEI; INTRACELLULAR PATHOGEN; GLUTATHIONE; SYSTEM;

D O I：

10.1016/j.chom.2015.06.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Intracellular bacteria exploit host cytosolic signals to upregulate virulence genes. In this issue of Cell Host & Microbe, Wong et al. (2015) show that Burkholderia pseudomallei senses host cytosolic glutathione, a low-molecular-weight thiol, through the membrane-bound histidine sensor kinase VirA, highlighting the importance of inter-kingdom signaling in bacterial pathogenesis.

引用

页码：7 / 8

页数：2

共 11 条

[1] The Cluster 1 Type VI Secretion System Is a Major Virulence Determinant in Burkholderia pseudomallei [J].

Burtnick, Mary N. ;

Brett, Paul J. ;

Harding, Sarah V. ;

Ngugi, Sarah A. ;

Ribot, Wilson J. ;

Chantratita, Narisara ;

Scorpio, Angelo ;

Milne, Timothy S. ;

Dean, Rachel E. ;

Fritz, David L. ;

Peacock, Sharon J. ;

Prior, Joanne L. ;

Atkins, Timothy P. ;

DeShazer, David .

INFECTION AND IMMUNITY, 2011, 79 (04) :1512-1525

[2] Regulation of Type VI Secretion System during Burkholderia pseudomallei Infection [J].

Chen, Yahua ;

Wong, Jocelyn ;

Sun, Guang Wen ;

Liu, Yichun ;

Tan, Gek-Yen Gladys ;

Gan, Yunn-Hwen .

INFECTION AND IMMUNITY, 2011, 79 (08) :3064-3073

[3] Signal detection and target gene induction by the CpxRA two-component system [J].

DiGiuseppe, PA ;

Silhavy, TJ .

JOURNAL OF BACTERIOLOGY, 2003, 185 (08) :2432-2440

[4] Listeria monocytogenes - from saprophyte to intracellular pathogen [J].

Freitag, Nancy E. ;

Port, Gary C. ;

Miner, Maurine D. .

NATURE REVIEWS MICROBIOLOGY, 2009, 7 (09) :623-628

[5] Molecular Insights into Burkholderia pseudomallei and Burkholderia mallei Pathogenesis [J].

Galyov, Edouard E. ;

Brett, Paul J. ;

DeShazer, David .

ANNUAL REVIEW OF MICROBIOLOGY, VOL 64, 2010, 2010, 64 :495-517

[6] Inter-kingdom signalling: communication between bacteria and their hosts [J].

Hughes, David T. ;

Sperandio, Vanessa .

NATURE REVIEWS MICROBIOLOGY, 2008, 6 (02) :111-120

[7] Identification of Burkholderia pseudomallei genes required for the intracellular life cycle and in vivo virulence [J].

Pilatz, Sabine ;

Breitbach, Katrin ;

Hein, Nadine ;

Fehlhaber, Beate ;

Schulze, Jessika ;

Brenneke, Birgit ;

Eberl, Leo ;

Steinmetz, Ivo .

INFECTION AND IMMUNITY, 2006, 74 (06) :3576-3586

[8] Glutathione activates virulence gene expression of an intracellular pathogen [J].

Reniere, Michelle L. ;

Whiteley, Aaron T. ;

Hamilton, Keri L. ;

John, Sonya M. ;

Lauer, Peter ;

Brennan, Richard G. ;

Portnoy, Daniel A. .

NATURE, 2015, 517 (7533) :170-U100

[9] Glutathione and its role in cellular functions [J].

Sies, H .

FREE RADICAL BIOLOGY AND MEDICINE, 1999, 27 (9-10) :916-921

[10] Host Cytosolic Glutathione Sensing by a Membrane Histidine Kinase Activates the Type VI Secretion System in an Intracellular Bacterium [J].

Wong, Jocelyn ;

Chen, Yahua ;

Gan, Yunn-Hwen .

CELL HOST & MICROBE, 2015, 18 (01) :38-48

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