Fungal immunomodulatory proteins: characteristic, potential antitumor activities and their molecular mechanisms

被引：49

作者：

Li, Qi-Zhang ^{[1
,2
,3
]}

Zheng, Yu-Zhang ^{[1
,2
]}

Zhou, Xuan-Wei ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Engn Res Ctr Therapeut Antibody, Minist Educ, Shanghai 200240, Peoples R China

[3] Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Aquat Econ Anim, Guangzhou 510275, Guangdong, Peoples R China

来源：

DRUG DISCOVERY TODAY | 2019年 / 24卷 / 01期

关键词：

TELOMERASE REVERSE-TRANSCRIPTASE; LUNG-CANCER CELLS; GANODERMA-MICROSPORUM; INTERFERON-GAMMA; FIP-FVE; MIGRATION; AUTOPHAGY; GROWTH; INVASION; CALCIUM;

D O I：

10.1016/j.drudis.2018.09.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

During recent decades, >30 fungal immunomodulatory proteins (FIPs) have been found in a range of mushrooms and other fungi. Various pharmacological functions of FIPs have become important in the discovery and development of new drugs. In this review, we discuss some important factors, focusing on the use of amino acid sequence data to predict structural and physicochemical properties. We also discuss pharmacologic activities and possible mechanisms of the proteins with a focus on antitumor activities. Numerous other questions must also be addressed before FIPs can be widely accepted and used as antitumor agents.

引用

页码：307 / 314

页数：8

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