Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria

被引：26

作者：

Falkinham, Joseph O., III ^{[1
]}

Macri, Richard V. ^{[2
]}

Maisuria, Bhadreshkumar B. ^{[2
]}

Actis, Marcelo L. ^{[2
]}

Sugandhi, Eko W. ^{[2
]}

Williams, Andre A. ^{[2
]}

Snyder, Alyson V. ^{[1
]}

Jackson, Faunice R. ^{[1
]}

Poppe, Michael A. ^{[1
]}

Chen, Liang ^{[2
]}

Ganesh, Krithika ^{[1
]}

Gandour, Richard D. ^{[2
]}

机构：

[1] Virginia Polytech Inst & State Univ, Dept Biol Sci 0406, Blacksburg, VA 24061 USA

[2] Virginia Polytech Inst & State Univ, Dept Chem 0212, Blacksburg, VA 24061 USA

来源：

TUBERCULOSIS | 2012年 / 92卷 / 02期

关键词：

Dendritic amphiphiles; Nontuberculous mycobacteria; Anti-mycobacterial agents; Critical micelle concentration; Hemolytic activity; CHAIN FATTY-ACIDS; RAPIDLY GROWING MYCOBACTERIA; LONG-CHAIN; AVIUM COMPLEX; TRICARBOXYLATO AMPHIPHILES; ANTIMICROBIAL ACTIVITY; SIGNAL-TRANSDUCTION; ULCERANS INFECTION; MARINUM INFECTION; CHAULMOOGRIC ACID;

D O I：

10.1016/j.tube.2011.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anti-mycobacterial activities of nine series of dicarboxyl and tricarboxyl dendritic amphiphiles with one alkyl, two alkyl, and cholestanyl tails against Mycobacterium abscessus, Mycobacterium avium, Mycobacterium chelonae, Mycobacterium marinum and Mycobacterium smegmatis have been measured. The dendritic amphiphiles overcame the limited aqueous solubility of natural long-chain fatty acids, alcohols, and amines to enable profiling the susceptibilities of the different mycobacterial species to the physicochemical properties of these amphiphiles. Several dendritic amphiphiles showed strong anti-mycobacterial activity with high critical micelle concentrations and low hemolytic activities thereby offering platforms for the development of antibiotics of higher activity against nontuberculous mycobacteria. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：173 / 181

页数：9

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