Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults

被引：53

作者：

Deng, Shengwen ^{[1
,2
]}

Franklin, Crystal G. ^{[1
]}

O'Boyle, Michael ^{[1
]}

Zhang, Wei ^{[1
]}

Heyl, Betty L. ^{[1
]}

Jerabek, Paul A. ^{[1
]}

Lu, Hanzhang ^{[3
,4
,5
]}

Fox, Peter T. ^{[1
,6
,7
,8
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA

[2] Univ Hosp Cleveland Med Ctr, Dept Radiol, Cleveland, OH USA

[3] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Sch Med, Baltimore, MD USA

[4] Johns Hopkins Univ, Dept Biomed Engn, Sch Med, Baltimore, MD USA

[5] Kennedy Krieger Res Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA

[6] Univ Texas San Antonio, Glenn Biggs Inst Alzheimers Neurodegenerat Disord, Hlth Sci Ctr San Antonio, San Antonio, TX USA

[7] Univ Texas San Antonio, Hlth Sci Ctr, Dept Radiol, San Antonio, TX 78284 USA

[8] South Texas Vet Hlth Care Syst, San Antonio, TX USA

来源：

NEUROIMAGE | 2022年 / 250卷

基金：

美国国家卫生研究院;

关键词：

Voxel-Based; Physiology; Metabolism; Brain; Hemodynamics; PET; fMRI; BOLD; ALFF; fALFF; ReHo; VBP; CEREBRAL-BLOOD-FLOW; LOW-FREQUENCY FLUCTUATIONS; DIFFEOMORPHIC IMAGE REGISTRATION; FMRI BOLD SIGNAL; FUNCTIONAL CONNECTIVITY; HUMAN BRAIN; REGIONAL HOMOGENEITY; GLUCOSE-UTILIZATION; AEROBIC GLYCOLYSIS; OXYGEN EXTRACTION;

D O I：

10.1016/j.neuroimage.2022.118923

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Voxel-based physiological (VBP) variables derived from blood oxygen level dependent (BOLD) fMRI time-course variations include: amplitude of low frequency fluctuations (ALFF), fractional amplitude of low frequency fluctuations (fALFF) and regional homogeneity (ReHo). Although these BOLD-derived variables can detect between-group (e.g. disease vs control) spatial pattern differences, physiological interpretations are not well established. The primary objective of this study was to quantify spatial correspondences between BOLD VBP variables and PET measurements of cerebral metabolic rate and hemodynamics, being well-validated physiological standards. To this end, quantitative, whole-brain PET images of metabolic rate of glucose (MRGlu; (18)FDG) and oxygen (MRO2; (OO)-O-15), blood flow (BF; (H2O)-O-15) and blood volume (BV; C15O) were obtained in 16 healthy controls. In the same subjects, BOLD time-courses were obtained for computation of ALFF, fALFF and ReHo images. PET variables were compared pair-wise with BOLD variables. In group-averaged, across-region analyses, ALFF corresponded significantly only with BV (R = 0.64; p < 0.0001). fALFF corresponded most strongly with MRGlu (R = 0.79; p < 0.0001), but also significantly (p < 0.0001) with MRO2 (R = 0.68), BF (R = 0.68) and BV (R = 0.68). ReHo performed similarly to fALFF, with significant strong correspondence (p < 0.0001) with MRGlu (R = 0.78), MRO2 (R = 0.54), and, but less strongly with BF (R = 0.50) and BV (R = 0.50). Mutual information analyses further clarified these physiological interpretations. When conditioned by BV, ALFF retained no significant MRGlu, MRO2 or BF information. When conditioned by MRGlu, fALFF and ReHo retained no significant MRO2, BF or BV information. Of concern, however, the strength of PET-BOLD correspondences varied markedly by brain region, which calls for future investigation on physiological interpretations at a regional and per-subject basis.

引用

页数：13

共 170 条

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