Applications of Single-Molecule Vibrational Spectroscopic Techniques for the Structural Investigation of Amyloid Oligomers

被引：3

作者：

Vu, Katrin Ha Phuong ^{[1
,2
,3
]}

Blankenburg, Gerhard Heinrich ^{[1
,3
,4
]}

Lesser-Rojas, Leonardo ^{[5
,6
]}

Chou, Chia-Fu ^{[3
,7
]}

机构：

[1] Acad Sinica, Taiwan Int Grad Program, Nanosci & Technol Program, Taipei 11529, Taiwan

[2] Natl Tsing Hua Univ, Dept Engn & Syst Sci, Hsinchu 300044, Taiwan

[3] Acad Sinica, Inst Phys, Taipei 11529, Taiwan

[4] Natl Taiwan Univ, Dept Phys, Taipei 10617, Taiwan

[5] Univ Costa Rica, Res Ctr Atom Nucl & Mol Sci, San Jose 2060, Costa Rica

[6] Univ Costa Rica, Sch Phys, San Jose 2060, Costa Rica

[7] Acad Sinica, Res Ctr Appl Sci, Taipei 11529, Taiwan

来源：

MOLECULES | 2022年 / 27卷 / 19期

关键词：

vibrational spectroscopy; amyloid oligomers; amyloid intermediates; protein structure; single molecule; ENHANCED RAMAN-SPECTROSCOPY; ALPHA-SYNUCLEIN OLIGOMERS; IMPAIR SYNAPTIC PLASTICITY; SECONDARY STRUCTURE; METAL-IONS; COMMON MECHANISM; INFRARED-SENSOR; ATR-FTIR; FIBRILS; ALZHEIMERS;

D O I：

10.3390/molecules27196448

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyloid oligomeric species, formed during misfolding processes, are believed to play a major role in neurodegenerative and metabolic diseases. Deepening the knowledge about the structure of amyloid intermediates and their aggregation pathways is essential in understanding the underlying mechanisms of misfolding and cytotoxicity. However, structural investigations are challenging due to the low abundance and heterogeneity of those metastable intermediate species. Single-molecule techniques have the potential to overcome these difficulties. This review aims to report some of the recent advances and applications of vibrational spectroscopic techniques for the structural analysis of amyloid oligomers, with special focus on single-molecule studies.

引用

页数：19

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