An in-depth analysis of the HIV-1/AIDS dynamics by comprehensive mathematical modeling

被引：11
作者：
Joly, Marcel [1 ,2 ]
Pinto, Jose M. [1 ,3 ]
机构：
[1] Univ Sao Paulo, Dept Chem Engn, BR-05508900 Sao Paulo, Brazil
[2] Petr Brasileiro SA, Petrobras, Brazil
[3] Polytech Univ, Othmer Jacobs Dept Chem & Biol Engn, Brooklyn, NY 11201 USA
来源：
MATHEMATICAL AND COMPUTER MODELLING | 2012年 / 55卷 / 3-4期
基金：
巴西圣保罗研究基金会;
关键词：
HIV-1/AIDS infection; Mathematical model; Computational simulation; HUMAN-IMMUNODEFICIENCY-VIRUS; PRIMARY HIV-INFECTION; ACTIVE ANTIRETROVIRAL THERAPY; MONOCYTE-DERIVED MACROPHAGES; T-CELL; POPULATION-DYNAMICS; IMMUNE-RESPONSES; TYPE-1; INFECTION; LYMPHOCYTES; TRANSMISSION;
D O I：
10.1016/j.mcm.2011.08.008
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
This work presents major results from a novel dynamic model intended to deterministically represent the complex relation between HIV-1 and the human immune system. The novel structure of the model extends previous work by representing different host anatomic compartments under a more in-depth cellular and molecular immunological phenomenology. Recently identified mechanisms related to HIV-1 infection as well as other well known relevant mechanisms typically ignored in mathematical models of HIV-1 pathogenesis and immunology, such as cell-cell transmission, are also addressed. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：342 / 366
页数：25
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