Drug Disposition Classification Systems in Discovery and Development: A Comparative Review of the BDDCS, ECCS and ECCCS Concepts

被引：30

作者：

Camenisch, Gian P. ^{[1
]}

机构：

[1] Novartis Inst BioMed Res, Dept Drug Metab & Pharmacokinet, CH-4056 Basel, Switzerland

来源：

PHARMACEUTICAL RESEARCH | 2016年 / 33卷 / 11期

关键词：

BDDCS; drug disposition classification; ECCCS; ECCS; enzyme/transporter interplay; HUMAN RENAL CLEARANCE; HEPATIC-CLEARANCE; PERMEABILITY; PREDICTION; PHARMACOKINETICS; HUMANS; LIPOPHILICITY; METABOLISM; ASSIGNMENT; MECHANISM;

D O I：

10.1007/s11095-016-2001-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

BDDCS, ECCS and ECCCS are compound disposition classification concepts that aim to streamline, de-risk and speed-up drug development. Although all three systems have the same purpose and are based on classifying drugs into four main categories, they have different backgrounds and contrast in their criteria. Here the details, differences and most important applications of the three systems are reviewed with particular emphasis of their roles for drug discovery and development.

引用

页码：2583 / 2593

页数：11

共 31 条

[1] A THEORETICAL BASIS FOR A BIOPHARMACEUTIC DRUG CLASSIFICATION - THE CORRELATION OF IN-VITRO DRUG PRODUCT DISSOLUTION AND IN-VIVO BIOAVAILABILITY [J].

AMIDON, GL ;

LENNERNAS, H ;

SHAH, VP ;

CRISON, JR .

PHARMACEUTICAL RESEARCH, 1995, 12 (03) :413-420

[2] The use of BDDCS in classifying the permeability of marketed drugs [J].

Benet, Leslie Z. ;

Amidon, Gordon L. ;

Barends, Dirk M. ;

Lennernas, Hans ;

Polli, James E. ;

Shah, Vinod P. ;

Stavchansky, Salomon A. ;

Yu, Lawrence X. .

PHARMACEUTICAL RESEARCH, 2008, 25 (03) :483-488

[3] BDDCS, the Rule of 5 and drugability [J].

Benet, Leslie Z. ;

Hosey, Chelsea M. ;

Ursu, Oleg ;

Oprea, Tudor I. .

ADVANCED DRUG DELIVERY REVIEWS, 2016, 101 :89-98

[4] The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development [J].

Benet, Leslie Z. .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 102 (01) :34-42

[5] BDDCS Applied to Over 900 Drugs [J].

Benet, Leslie Z. ;

Broccatelli, Fabio ;

Oprea, Tudor I. .

AAPS JOURNAL, 2011, 13 (04) :519-547

[6] BDDCS Class Prediction for New Molecular Entities [J].

Broccatelli, Fabio ;

Cruciani, Gabriele ;

Benet, Leslie Z. ;

Oprea, Tudor I. .

MOLECULAR PHARMACEUTICS, 2012, 9 (03) :570-580

[7] Shapes of membrane permeability-lipophilicity curves: Extension of theoretical models with an aqueous pore pathway [J].

Camenisch, G ;

Folkers, G ;

van de Waterbeemd, H .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1998, 6 (04) :321-329

[8] Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight [J].

Camenisch, G ;

Alsenz, J ;

van de Waterbeemd, H ;

Folkers, G .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1998, 6 (04) :313-319

[9] The extended clearance model and its use for the interpretation of hepatobiliary elimination data [J].

Camenisch, Gian ;

Riede, Julia ;

Kunze, Annett ;

Huwyler, Jorg ;

Poller, Birk ;

Umehara, Kenichi .

ADMET AND DMPK, 2015, 3 (01) :1-14

[10] Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions [J].

Camenisch, Gian ;

Umehara, Ken-ichi .

BIOPHARMACEUTICS & DRUG DISPOSITION, 2012, 33 (04) :179-194

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