Lipid mediators of liver injury in nonalcoholic fatty liver disease

被引：44

作者：

Liangpunsakul, Suthat ^{[1
,2
,3
]}

Chalasani, Naga ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA

[3] Richard L Roudebush Vet Adm Med Ctr, Indianapolis, IN USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2019年 / 316卷 / 01期

基金：

美国国家卫生研究院;

关键词：

cell death; inflammation; lipotoxicity; nonalcoholic fatty liver disease; INFLAMMATORY EXTRACELLULAR VESICLES; INHIBITOR GS-0976 LEADS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; FREE-CHOLESTEROL; SIGNIFICANT IMPROVEMENTS; MOLECULAR-MECHANISMS; CERAMIDE PRODUCTION; MRI-PDFF; ACIDS;

D O I：

10.1152/ajpgi.00170.2018

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of histopathological phenotypes ranging from simple steatosis to more severe liver disease associated with cell injury, including nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. Only a subset of patients with NAFLD develop NASH from yet incompletely understood mechanisms. Emerging data suggest lipid species other than triglycerides as contributors to the pathogenesis of NASH. In this mini review, we focus on the recent data on the mechanisms of NASH, focusing on these lipid mediators and their potential as therapeutic targets in NASH.

引用

页码：G75 / G81

页数：7

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