BCG Therapy for Type 1 Diabetes: Restoration of Balanced Immunity and Metabolism

被引：51
作者：
Kuhtreiber, Willem M. [1 ,2 ]
Faustman, Denise L. [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Med, Immunobiol Labs, Boston, MA 02114 USA
[2] Harvard Med Sch, Boston, MA 02115 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2019年 / 30卷 / 02期
关键词：
BACILLE CALMETTE-GUERIN; MYCOBACTERIUM-TUBERCULOSIS; GUINEA-BISSAU; VACCINATION; PREVENTION; ADJUVANT; EXPRESSION; PROTECTION; REVERSAL; VACCINES;
D O I：
10.1016/j.tem.2018.11.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The bacillus Calmette-Guerin (BCG) vaccine is a microorganism developed as a vaccine for tuberculosis 100 years ago and used as therapy for bladder cancer 40 years ago. More recently, BCG has shown therapeutic promise for type 1 diabetes (T1D) and several other autoimmune diseases. In T1D, BCG restored blood sugars to near normal, even in patients with advanced disease of >20 years duration. This clinically important effect may be driven by resetting of the immune system and the shifting of glucose metabolism from overactive oxidative phosphorylation, a state of minimal sugar utilization, to aerobic glycolysis, a state of high glucose utilization, for energy production. The mechanistic findings support the Hygiene Hypothesis and reveal the immune and metabolic synergy of mycobacterial reintroduction in modern humans.
引用
收藏
页码：80 / 92
页数：13
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