High-value products from plants: the challenges of process optimization

被引：40

作者：

Fischer, Rainer ^{[1
,2
]}

Vasilev, Nikolay ^{[1
]}

Twyman, Richard M. ^{[3
]}

Schillberg, Stefan ^{[1
]}

机构：

[1] IME, Fraunhofer Inst Mol Biol & Appl Ecol, Aachen, Germany

[2] Rhein Westfal TH Aachen, Inst Mol Biotechnol, Aachen, Germany

[3] TRM Ltd, York YO43 3WE, N Yorkshire, England

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2015年 / 32卷

关键词：

RECOMBINANT PHARMACEUTICAL PROTEINS; DOWNSTREAM PROCESSES; SUSPENSION-CULTURE; TISSUE-CULTURES; CELL-LINES; TOBACCO; ANTIBODY; PURIFICATION; MODELS; GROWTH;

D O I：

10.1016/j.copbio.2014.12.018

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Plants can be used to produce a diverse repertoire of complex small-molecule compounds and recombinant proteins that are valuable as industrial and pharmaceutical products. But as we move from proof-of-principle experiments and begin to consider the realistic prospects of commercial production, the focus must shift from the achievement of target molecule production and move towards quality, purity and yield aspects that determine commercial feasibility. This review describes some of the recent advances that have been implemented to improve the development of integrated production processes for high-value molecules expressed in plants, including the introduction of novel procedures to increase the likelihood of regulatory acceptance.

引用

页码：156 / 162

页数：7

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