Current perspectives on benzoflavone analogues with potent biological activities: A review

被引：1

作者：

Liu, Guangxin ^{[1
]}

Zhao, Zefeng ^{[3
]}

Li, Mengjia ^{[1
]}

Zhao, Mingrui ^{[2
]}

Xu, Tong ^{[1
]}

Wang, Shaohui ^{[2
]}

Zhang, Yi ^{[1
,2
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China

[3] Shanxi Univ Chinese Med, Coll Acupuncture & Massage, Xixian New Area 712046, Shaanxi, Peoples R China

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2022年 / 15卷 / 09期

基金：

国家重点研发计划;

关键词：

Benzoflavone; Cytochrome P450; Antitumor; Central nervous system; Anti-inflammatory; SAR; Derivatives; CELL-CYCLE ARREST; CHALCONE DERIVATIVES; SYNTHETIC CHALCONES; AH RECEPTOR; INHIBITORS; APOPTOSIS; FLAVONOIDS; ALPHA; 7,8-BENZOFLAVONE; CYTOTOXICITY;

D O I：

10.1016/j.arabjc.2022.104109

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Medicinal chemistry investigators have isolated and synthesized benzoflavone analogues with diverse bioactivities including enzyme inhibitory activity, central nervous system (CNS) activity, anti-inflammatory activity, anti-microorganism activity, hypoglycemic activity, and receptor modulating potential. SAR (Structure-Activity Relationship) studies have been conducted extensively and plenty of benzoflavone analogues have been prepared for potential targets. Herein, we review the pharmacology properties and SAR for benzoflavone analogues, and provide a brief summarization of synthetic strategies, wishing to give perspective on the research and development of benzoflavone derivatives. (C) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

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页数：20

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