Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission

被引：57
|
作者：
Chen, Ji-An [1 ]
Pan, Hongming [2 ]
Wang, Zhijun [2 ]
Gao, Jie [1 ]
Tan, Jiahui [1 ]
Ouyang, Zhirong [1 ]
Guo, Wei [2 ]
Gu, Xianfeng [1 ]
机构：
[1] Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201301, Peoples R China
[2] Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 201301, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 18期
关键词：
BETA-GALACTOSIDASE ACTIVITY; SELECTIVE DETECTION; FLUORESCENT-PROBE; STRUCTURAL BASIS; TRACKING; DESIGN; TUMOR; FLUOROPHORES; NANOPROBE; BRIGHT;
D O I：
10.1039/c9cc09158k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We herein develop two beta-galactosidase (beta-Gal) activatable NIR fluorescent probes for visualizing ovarian cancers. Particularly, probe BOD-M-beta Gal produced NIR-II emission light at 900-1300 nm upon beta-Gal activation. By using our activatable and target specific NIR-II probe for deep-tissue imaging of beta-Gal overexpressed ovarian cancer cells, rapid and accurate imaging of ovarian tumors in nude mice was achieved.
引用
收藏
页码：2731 / 2734
页数：4
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