Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission

被引：60

作者：

Chen, Ji-An ^{[1
]}

Pan, Hongming ^{[2
]}

Wang, Zhijun ^{[2
]}

Gao, Jie ^{[1
]}

Tan, Jiahui ^{[1
]}

Ouyang, Zhirong ^{[1
]}

Guo, Wei ^{[2
]}

Gu, Xianfeng ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201301, Peoples R China

[2] Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 201301, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 18期

关键词：

BETA-GALACTOSIDASE ACTIVITY; SELECTIVE DETECTION; FLUORESCENT-PROBE; STRUCTURAL BASIS; TRACKING; DESIGN; TUMOR; FLUOROPHORES; NANOPROBE; BRIGHT;

D O I：

10.1039/c9cc09158k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We herein develop two beta-galactosidase (beta-Gal) activatable NIR fluorescent probes for visualizing ovarian cancers. Particularly, probe BOD-M-beta Gal produced NIR-II emission light at 900-1300 nm upon beta-Gal activation. By using our activatable and target specific NIR-II probe for deep-tissue imaging of beta-Gal overexpressed ovarian cancer cells, rapid and accurate imaging of ovarian tumors in nude mice was achieved.

引用

页码：2731 / 2734

页数：4

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