Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus

被引：32

作者：

Chen, Zhenzhong ^{[1
]}

Tong, Ling ^{[1
]}

Peng, Yuanli ^{[1
]}

Wu, Jizhou ^{[1
]}

Zhao, Xiaoya ^{[2
]}

Ruan, Hanli ^{[1
]}

Pi, Huifang ^{[1
]}

Zhang, Peng ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Sch Pharm, Wuhan 430030, Peoples R China

[2] Hubei Entry Exit Inspect & Quarantine Bur, Wuhan, Peoples R China

来源：

PHYTOCHEMISTRY | 2015年 / 116卷

关键词：

Rubus innominatus; Rosaceae; Triterpenes; Anti-inflammatory activity; TRITERPENE; ACID; INFLAMMATION;

D O I：

10.1016/j.phytochem.2015.04.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two nortriterpenes (rubuminatus A and B), which contain a distinctive contracted a five-membered A-ring ursane-type skeleton, and six triterpenes along with 17 known triterpenes were isolated from the roots of Rubus innominatus S. Moore. These structures were determined to be 19 alpha-hydroxy-2-oxonor- A(3)-urs-12-en-28-oic acid, 1 beta,19 alpha-dihydroxy-2-oxo-nor-A(3)-urs-12-en-28-oic acid, 1 beta,2 alpha,3 alpha, 19 alpha-tetrahy droxyurs-12-en-23-formyl-28-oic acid, 1 beta,2 alpha,3 alpha,19 alpha,23- pentahydroxyurs-11-en-28-oic acid, 1-oxo-siaresinolic acid, 2 alpha,3 alpha-dihydroxyolean-11,13(18)-dien-19 beta,28-olide, 1 beta,2 alpha,3 alpha-trihydroxy-19-oxo- 18,19-seco-urs-11,13(18)-dien-28-oic acid, and 2-O-benzoyl alphitolic acid based on extensive spectroscopic analyses. In vitro anti-inflammatory abilities to modulate the production of TNF-alpha, and IL-6 in LPS-induced RAW 264.7 macrophages of the compounds were determined. Rubuminatus A and B, as well as 1-oxo-siaresinolic acid and 2 alpha,3 alpha-dihydroxyolean-11,13(18)-dien-19 beta,28-olide, exhibited significant inhibitory effects on these cytokines. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：329 / 336

页数：8

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