Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities

被引:67
作者
Smith, Caren E. [1 ]
Fullerton, Stephanie M. [2 ]
Dookeran, Keith A. [3 ,4 ]
Hampel, Heather [5 ]
Tin, Adrienne [6 ]
Maruthur, Nisa M. [6 ,7 ,8 ]
Schisler, Jonathan C. [9 ]
Henderson, Jeffrey A. [10 ]
Tucker, Katherine L. [11 ]
Ordovas, Jose M. [1 ]
机构
[1] Tufts Univ, Nutr & Genom Lab, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA
[2] Univ Washington, Dept Bioeth & Humanities, Seattle, WA 98195 USA
[3] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL USA
[4] Canc Fdn Minor & Underserved Populat, Chicago, IL USA
[5] Ohio State Univ, Div Human Genet, Ctr Comprehens Canc, Columbus, OH 43210 USA
[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[7] Johns Hopkins Univ, Sch Med, Div Gen Internal Med, Baltimore, MD 21218 USA
[8] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21218 USA
[9] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC USA
[10] Black Hills Ctr Amer Indian Hlth, Rapid City, SD USA
[11] Univ Massachusetts, Clin Lab & Nutr Sci, Lowell, MA USA
关键词
STAGE RENAL-DISEASE; BREAST-CANCER; RACIAL-DIFFERENCES; SOCIOECONOMIC-STATUS; VARIANTS; AFRICAN; STATISTICS; DIAGNOSIS; SUBTYPES; RISK;
D O I
10.1377/hlthaff.2015.1476
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Evidence shows that both biological and nonbiological factors contribute to health disparities. Genetics, in particular, plays a part in how common diseases manifest themselves. Today, unprecedented advances in genetically based diagnoses and treatments provide opportunities for personalized medicine. However, disadvantaged groups may lack access to these advances, and treatments based on research on non-Hispanic whites might not be generalizable to members of minority groups. Unless genetic technologies become universally accessible, existing disparities could be widened. Addressing this issue will require integrated strategies, including expanding genetic research, improving genetic literacy, and enhancing access to genetic technologies among minority populations in a way that avoids harms such as stigmatization.
引用
收藏
页码:1367 / 1373
页数:7
相关论文
共 48 条
[1]   What hinders minority ethnic access to cancer genetics services and what may help? [J].
Allford, Anna ;
Qureshi, Nadeem ;
Barwell, Julian ;
Lewis, Celine ;
Kai, Joe .
EUROPEAN JOURNAL OF HUMAN GENETICS, 2014, 22 (07) :866-874
[2]  
[Anonymous], JAMA
[3]  
[Anonymous], PREC MED IN
[4]  
[Anonymous], AM J HUM GENET
[5]   Racial differences in the use of BRCA1/2 testing among women with a family history of breast or ovarian cancer [J].
Armstrong, K ;
Micco, E ;
Carney, A ;
Stopfer, J ;
Putt, M .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (14) :1729-1736
[6]   Descriptive analysis of estrogen receptor (ER)negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype - A population-based study from the California Cancer Registry [J].
Bauer, Katrina R. ;
Brown, Monica ;
Cress, Rosemary D. ;
Parise, Carol A. ;
Caggiano, Vincent .
CANCER, 2007, 109 (09) :1721-1728
[7]   Racial Variation in Breast Tumor Promoter Methylation in the Carolina Breast Cancer Study [J].
Conway, Kathleen ;
Edmiston, Sharon N. ;
Tse, Chiu-Kit ;
Bryant, Christopher ;
Kuan, Pei Fen ;
Hair, Brionna Y. ;
Parrish, Eloise A. ;
May, Ryan ;
Swift-Scanlan, Theresa .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2015, 24 (06) :921-930
[8]   Natural and sexual selection in a monogamous historical human population [J].
Courtiol, Alexandre ;
Pettay, Jenni E. ;
Jokela, Markus ;
Rotkirch, Anna ;
Lummaa, Virpi .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (21) :8044-8049
[9]   Race, socioeconomic status, and breast carcinoma in the US - What have we learned from clinical studies? [J].
Cross, CK ;
Harris, J ;
Recht, A .
CANCER, 2002, 95 (09) :1988-1999
[10]   A new genome-driven integrated classification of breast cancer and its implications [J].
Dawson, Sarah-Jane ;
Rueda, Oscar M. ;
Aparicio, Samuel ;
Caldas, Carlos .
EMBO JOURNAL, 2013, 32 (05) :617-628