Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer

被引：33
|
作者：
Seol, Ho Jun [3 ]
Jin, Juyoun [3 ,4 ,5 ]
Seong, Dong-Ho [6 ]
Joo, Kyeung Min [4 ,5 ,7 ]
Kang, Wonyoung [3 ,4 ,5 ]
Yang, Heekyoung [3 ,4 ,5 ]
Kim, Jandi [7 ]
Shin, Chul Soo [6 ]
Kim, Yonghyun [3 ,4 ,5 ]
Kim, Kang Ho [3 ,4 ,5 ]
Kong, Doo-Sik [3 ]
Lee, Jung-Ii [3 ]
Aboody, Karen S. [8 ]
Lee, Hong Jun [1 ,2 ]
Kim, Seung U. [1 ,2 ]
Nam, Do-Hyun [3 ,4 ,5 ]
机构：
[1] Univ British Columbia, Div Neurol, Dept Med, Vancouver, BC V6T 2B5, Canada
[2] Chung Ang Univ, Coll Med, Med Res Inst, Seoul 156756, South Korea
[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg, Seoul 135710, South Korea
[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Samsung Biomed Res Inst, Seoul 135710, South Korea
[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Canc Stem Cell Res Ctr, Seoul 135710, South Korea
[6] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 120749, South Korea
[7] Seoul Natl Univ, Coll Med, Dept Anat, Seoul, South Korea
[8] City Hope Natl Med Ctr, Div Hematol Hematopoiet Cell Transplantat & Neusc, Duarte, CA 91010 USA
来源：
CANCER LETTERS | 2011年 / 311卷 / 02期
关键词：
CPT-11; Carboxyl esterase (CE); Metastatic brain tumor; IRINOTECAN; CPT-11; TRANSPLANTATION; BEVACIZUMAB; TROPISM; DELIVER; GROWTH; TUMORS;
D O I：
10.1016/j.canlet.2011.07.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain metastases located in the opposite hemisphere. The treatment also significantly decreased tumor volume in immune-deficient mice bearing MDA-MB-435 tumors when F3.CE cells were transplanted into the contralateral hemisphere. The survival rate was significantly prolonged with the treatment with F3.CE and CPT-11. This strategy may be considered as an effective treatment regimen for brain metastases. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：152 / 159
页数：8
相关论文
共 50 条
  • [31] STAT3 as a novel therapeutic target in human breast cancer stem cells
    Lin, Li
    Hutzen, Brian
    Peng, Zhengang
    Lin, Huey-Jen
    Li, Pui-Kai
    Li, Chenglong
    Wicha, Max
    Lin, Jiayuh
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [32] Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells
    Tomoyuki Koga
    Isaac A. Chaim
    Jorge A. Benitez
    Sebastian Markmiller
    Alison D. Parisian
    Robert F. Hevner
    Kristen M. Turner
    Florian M. Hessenauer
    Matteo D’Antonio
    Nam-phuong D. Nguyen
    Shahram Saberi
    Jianhui Ma
    Shunichiro Miki
    Antonia D. Boyer
    John Ravits
    Kelly A. Frazer
    Vineet Bafna
    Clark C. Chen
    Paul S. Mischel
    Gene W. Yeo
    Frank B. Furnari
    Nature Communications, 11
  • [33] What can we learn about breast cancer from stem cells?
    Clarke, Michael F.
    HORMONAL CARCINOGENESIS V, 2008, 617 : 17 - 22
  • [34] Analysis of Neural Stem Cells from Human Cortical Brain Structures In Vitro
    M. A. Aleksandrova
    R. A. Poltavtseva
    M. V. Marei
    G. T. Sukhikh
    Bulletin of Experimental Biology and Medicine, 2016, 161 : 197 - 208
  • [35] Formation of Neuroepithelial Structures in Culture of Neural Stem Cells from Human Brain
    O. V. Podgornyi
    R. A. Poltavtseva
    M. V. Marei
    G. T. Sukhikh
    M. A. Aleksandrova
    Bulletin of Experimental Biology and Medicine, 2005, 140 : 113 - 117
  • [36] Analysis of Neural Stem Cells from Human Cortical Brain Structures In Vitro
    Aleksandrova, M. A.
    Poltavtseva, R. A.
    Marei, M. V.
    Sukhikh, G. T.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2016, 161 (01) : 197 - 208
  • [37] Prospective isolation of neural stem and progenitor cells from the developing human brain
    Liu, Daniel Dan
    He, Joy Q.
    Uchida, Nobuko
    Weissman, Irving L.
    Sinha, Rahul
    STAR PROTOCOLS, 2023, 4 (04):
  • [38] Formation of neuroepithelial structures in culture of neural stem cells from human brain
    Podgornyi, OV
    Poltavtseva, RA
    Marei, MV
    Sukhikh, GT
    Aleksandrova, MA
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2005, 140 (01) : 113 - 117
  • [39] Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-β via their tumor tropism to selectively target human hepatocarcinoma cells
    B-R Yi
    K-A Hwang
    N-H Kang
    S U Kim
    E-B Jeung
    H-C Kim
    K-C Choi
    Cancer Gene Therapy, 2012, 19 : 644 - 651
  • [40] Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-β via their tumor tropism to selectively target human hepatocarcinoma cells
    Yi, B-R
    Hwang, K-A
    Kang, N-H
    Kim, S. U.
    Jeung, E-B
    Kim, H-C
    Choi, K-C
    CANCER GENE THERAPY, 2012, 19 (09) : 644 - 651
12345