Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer

被引：33
|
作者：
Seol, Ho Jun [3 ]
Jin, Juyoun [3 ,4 ,5 ]
Seong, Dong-Ho [6 ]
Joo, Kyeung Min [4 ,5 ,7 ]
Kang, Wonyoung [3 ,4 ,5 ]
Yang, Heekyoung [3 ,4 ,5 ]
Kim, Jandi [7 ]
Shin, Chul Soo [6 ]
Kim, Yonghyun [3 ,4 ,5 ]
Kim, Kang Ho [3 ,4 ,5 ]
Kong, Doo-Sik [3 ]
Lee, Jung-Ii [3 ]
Aboody, Karen S. [8 ]
Lee, Hong Jun [1 ,2 ]
Kim, Seung U. [1 ,2 ]
Nam, Do-Hyun [3 ,4 ,5 ]
机构：
[1] Univ British Columbia, Div Neurol, Dept Med, Vancouver, BC V6T 2B5, Canada
[2] Chung Ang Univ, Coll Med, Med Res Inst, Seoul 156756, South Korea
[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg, Seoul 135710, South Korea
[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Samsung Biomed Res Inst, Seoul 135710, South Korea
[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Canc Stem Cell Res Ctr, Seoul 135710, South Korea
[6] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 120749, South Korea
[7] Seoul Natl Univ, Coll Med, Dept Anat, Seoul, South Korea
[8] City Hope Natl Med Ctr, Div Hematol Hematopoiet Cell Transplantat & Neusc, Duarte, CA 91010 USA
来源：
CANCER LETTERS | 2011年 / 311卷 / 02期
关键词：
CPT-11; Carboxyl esterase (CE); Metastatic brain tumor; IRINOTECAN; CPT-11; TRANSPLANTATION; BEVACIZUMAB; TROPISM; DELIVER; GROWTH; TUMORS;
D O I：
10.1016/j.canlet.2011.07.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain metastases located in the opposite hemisphere. The treatment also significantly decreased tumor volume in immune-deficient mice bearing MDA-MB-435 tumors when F3.CE cells were transplanted into the contralateral hemisphere. The survival rate was significantly prolonged with the treatment with F3.CE and CPT-11. This strategy may be considered as an effective treatment regimen for brain metastases. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：152 / 159
页数：8
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