Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer

被引：33

作者：

Seol, Ho Jun ^{[3
]}

Jin, Juyoun ^{[3
,4
,5
]}

Seong, Dong-Ho ^{[6
]}

Joo, Kyeung Min ^{[4
,5
,7
]}

Kang, Wonyoung ^{[3
,4
,5
]}

Yang, Heekyoung ^{[3
,4
,5
]}

Kim, Jandi ^{[7
]}

Shin, Chul Soo ^{[6
]}

Kim, Yonghyun ^{[3
,4
,5
]}

Kim, Kang Ho ^{[3
,4
,5
]}

Kong, Doo-Sik ^{[3
]}

Lee, Jung-Ii ^{[3
]}

Aboody, Karen S. ^{[8
]}

Lee, Hong Jun ^{[1
,2
]}

Kim, Seung U. ^{[1
,2
]}

Nam, Do-Hyun ^{[3
,4
,5
]}

机构：

[1] Univ British Columbia, Div Neurol, Dept Med, Vancouver, BC V6T 2B5, Canada

[2] Chung Ang Univ, Coll Med, Med Res Inst, Seoul 156756, South Korea

[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg, Seoul 135710, South Korea

[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Samsung Biomed Res Inst, Seoul 135710, South Korea

[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Canc Stem Cell Res Ctr, Seoul 135710, South Korea

[6] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 120749, South Korea

[7] Seoul Natl Univ, Coll Med, Dept Anat, Seoul, South Korea

[8] City Hope Natl Med Ctr, Div Hematol Hematopoiet Cell Transplantat & Neusc, Duarte, CA 91010 USA

来源：

CANCER LETTERS | 2011年 / 311卷 / 02期

关键词：

CPT-11; Carboxyl esterase (CE); Metastatic brain tumor; IRINOTECAN; CPT-11; TRANSPLANTATION; BEVACIZUMAB; TROPISM; DELIVER; GROWTH; TUMORS;

D O I：

10.1016/j.canlet.2011.07.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain metastases located in the opposite hemisphere. The treatment also significantly decreased tumor volume in immune-deficient mice bearing MDA-MB-435 tumors when F3.CE cells were transplanted into the contralateral hemisphere. The survival rate was significantly prolonged with the treatment with F3.CE and CPT-11. This strategy may be considered as an effective treatment regimen for brain metastases. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：152 / 159

页数：8

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