Theranostic nanosystems for targeted cancer therapy

被引：88
作者：
Kang, Homan [1 ,2 ]
Hu, Shuang [1 ,2 ,3 ]
Cho, Mi Hyeon [4 ]
Hong, Suk Ho [4 ]
Choi, Yongdoo [4 ]
Choi, Hak Soo [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Radiol, Gordon Ctr Med Imaging, Boston, MA 02114 USA
[2] Harvard Med Sch, Boston, MA 02114 USA
[3] Sichuan Univ, West China Sch Med, West China Hosp, Dept Nucl Med, Chengdu 601141, Sichuan, Peoples R China
[4] Natl Canc Ctr, Biomarker Branch, 323 Ilsan Ro, Goyang 10408, Gyeonggi, South Korea
来源：
NANO TODAY | 2018年 / 23卷
关键词：
Targeted therapy; Functional nanoparticle; Organ-specific targeting; Diagnostic imaging; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; PHOTODYNAMIC THERAPY; MAGNETIC NANOPARTICLES; POLYMERIC MICELLES; POLYPYRROLE NANOPARTICLES; ENHANCED PERMEABILITY; PHOTOTHERMAL THERAPY; TRIGGERED RELEASE; BREAST-CANCER;
D O I：
10.1016/j.nantod.2018.11.001
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nanomaterials have revolutionized cancer imaging, diagnosis, and treatment. Multifunctional nanopartides in particular have been designed for targeted cancer therapy by modulating their physicochemical properties to be delivered to the target and activated by internal and/or external stimuli. This review will focus on the fundamental "chemical" design considerations of stimuli-responsive nanosystems to achieve favorable tumor targeting beyond biological barriers and, furthermore, enhance targeted cancer therapy. In addition, we will summarize innovative smart nanosystems responsive to external stimuli (e.g., light, magnetic field, ultrasound, and electric field) and internal stimuli in the tumor microenvironment (e.g., pH, enzyme, redox potential, and oxidative stress). (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：59 / 72
页数：14
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