Anandamide: some like it hot

被引：178
作者：
Di Marzo, V
Bisogno, T
De Petrocellis, L
机构：
[1] CNR, Ist Chim Mol Interesse Biol, I-80072 Arco Felice, Napoli, Italy
[2] CNR, Ist Cibernet, I-80072 Arco Felice, Napoli, Italy
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 07期
关键词：
D O I：
10.1016/S0165-6147(00)01712-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Anandamide was the first endogenous ligand of cannabinoid receptors to be discovered in 1992. Yet, this compound also efficiently activates receptors specific for capsaicin, known as vanilloid type 1 receptors (VR1). Whether anandamide is a physiological VR1 ligand is controversial. However, very recent reports demonstrate that activation of VR1 by anandamide can be significantly enhanced by various regulatory factors, suggesting that this compound might act as an 'endovanilloid' under certain conditions.
引用
收藏
页码：346 / 349
页数：4
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