Synthesis of N-Nitroso CHF2-Pyrazolines and Their Transformation into CHF2-Isoxazolines and -Pyrazoles

被引：25

作者：

Lebed, Pavlo S. ^{[1
,2
,3
]}

Fenneteau, Johan ^{[4
]}

Wu, Yong ^{[5
,6
]}

Cossy, Janine ^{[4
]}

Mykhailiuk, Pavel K. ^{[1
]}

机构：

[1] Taras Shevchenko Natl Univ Kyiv, Dept Chem, Volodymyrska 64, UA-01601 Kiev, Ukraine

[2] Enamine Ltd, Chervonotkatska 78, UA-02094 Kiev, Ukraine

[3] Taras Shevchenko Natl Univ Kyiv, ChemBioCtr, Volodymyrska 64, UA-01601 Kiev, Ukraine

[4] PSL Res Univ, ESPCI Paris 8281, Lab Chim Organ, Inst Chem Biol & Innovat CBI UMR, 10 Rue Vauquelin, F-75231 Paris 05, France

[5] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting, Chengdu 610041, Sichuan, Peoples R China

[6] Sichuan Univ, West China Sch Pharm, Dept Med Chem, Chengdu 610041, Sichuan, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 41期

关键词：

Fluorine; Heterocycles; Alkenes; Diazo compounds; Cycloaddition; Fluorinated compounds; FLUORINATED TEBUFENPYRAD ANALOGS; ELECTRON-DEFICIENT ALKYNES; IN-SITU GENERATION; ONE-POT SYNTHESIS; TRIFLUOROMETHYL DIAZOMETHANE; MEDICINAL CHEMISTRY; 3-COMPONENT SYNTHESIS; 2,2,2-TRIFLUORODIAZOETHANE; CYCLOADDITION; DIFLUOROMETHYLATION;

D O I：

10.1002/ejoc.201700803

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Nitroso CHF2-pyrazolines were synthesized from in situ generated difluoromethyldiazomethane (CF2HCHN2), tert-butyl isonitrite (tBuONO), and alkenes. The synthesis of representative CHF2-pyrazoles and CHF2-oxazolines was also performed.

引用

页码：6114 / 6120

页数：7

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