Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type

被引：127

作者：

Popp, Julius ^{[1
,2
,3
]}

Wolfsgruber, Steffen ^{[1
,4
]}

Heuser, Isabella ^{[5
]}

Peters, Oliver ^{[5
]}

Huell, Michael ^{[6
]}

Schroeder, Johannes ^{[7
]}

Moeller, Hans-Juergen ^{[8
]}

Lewczuk, Piotr ^{[9
]}

Schneider, Anja ^{[10
,11
]}

Jahn, Holger ^{[12
]}

Luckhaus, Christian ^{[13
]}

Perneczky, Robert ^{[14
]}

Froelich, Lutz ^{[15
]}

Wagner, Michael ^{[1
,4
]}

Maier, Wolfgang ^{[1
,4
]}

Wiltfang, Jens ^{[16
]}

Kornhuber, Johannes ^{[9
]}

Jessen, Frank ^{[1
,4
]}

机构：

[1] Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany

[2] Univ Lausanne Hosp, Leenaards Memory Ctr, Dept Psychiat, Lausanne, Switzerland

[3] Univ Lausanne Hosp, Leenaards Memory Ctr, Dept Clin Neurosci, Lausanne, Switzerland

[4] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[5] Charite, Dept Psychiat & Psychotherapy, Berlin, Germany

[6] Univ Hosp Freiburg, Ctr Geriatr Med & Gerontol, Freiburg, Germany

[7] Heidelberg Univ, Dept Psychiat & Psychotherapy, Heidelberg, Germany

[8] Univ Munich, Dept Psychiat, D-80539 Munich, Germany

[9] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, D-91054 Erlangen, Germany

[10] Univ Gottingen, Dept Psychiat & Psychotherapy, D-37073 Gottingen, Germany

[11] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[12] Univ Hamburg, Dept Psychiat & Psychotherapy, Hamburg, Germany

[13] Univ Dusseldorf, Dept Psychiat & Psychotherapy, Dusseldorf, Germany

[14] Tech Univ Munich, Dept Psychiat & Psychotherapy, D-80290 Munich, Germany

[15] Cent Inst Mental Hlth, Mannheim, Germany

[16] Univ Gottingen, Univ Med Ctr UMG, Dept Psychiat & Psychotherapy, D-37073 Gottingen, Germany

来源：

NEUROBIOLOGY OF AGING | 2015年 / 36卷 / 02期

关键词：

Hypothalamic-pituitary-adrenal axis; Cortisol; Cerebrospinal fluid; Cognitive decline; Mild cognitive impairment; Alzheimer's disease; MILD COGNITIVE IMPAIRMENT; AMYLOID-BETA; TAU PATHOLOGY; SALIVARY CORTISOL; STRESS SYSTEM; CSF CORTISOL; OLDER-ADULTS; GLUCOCORTICOIDS; DEPRESSION; GENOTYPE;

D O I：

10.1016/j.neurobiolaging.2014.10.031

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Increased peripheral and central nervous system cortisol levels have been reported in Alzheimer's disease (AD) and may reflect dysfunction of cerebral components of the hypothalamic-pituitary-adrenal (HPA) axis. However, brain exposure to high cortisol concentrations may also accelerate disease progression and cognitive decline. The objectives of this study were to investigate whether HPA-axis dysregulation occurs at early clinical stages of AD and whether plasma and CSF cortisol levels are associated with clinical disease progression. Morning plasma and CSF cortisol concentrations were obtained from the subjects with AD dementia, mild cognitive impairment of AD type (MCI-AD), MCI of other type (MCI-O), and controls with normal cognition included in a multicenter study from the German Dementia Competence Network. A clinical and neuropsychological follow-up was performed in a subgroup of participants with MCI-AD, MCI-O, and AD dementia. CSF cortisol concentrations were increased in the subjects with AD dementia or MCI-AD compared with subjects with MCI-O or normal cognition. After controlling for possible confounders including CSF measures of amyloid beta1-42 and total tau, higher baseline CSF cortisol levels were associated with faster clinical worsening and cognitive decline in MCI-AD. The findings suggest that HPA-axis dysregulation occurs at the MCI stage of AD and may accelerate disease progression and cognitive decline. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：601 / 607

页数：7

共 42 条

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