Comparison of extracellular phospholipase activities in clinical and environmental Aspergillus fumigatus isolates

被引：31

作者：

Birch, M

Denning, DW

Robson, GD

机构：

[1] Univ Manchester, Hope Hosp, Dept Med, Salford M6 8HD, Lancs, England

[2] Univ Manchester, Wythenshawe Hosp, Educ & Res Ctr, Manchester, Lancs, England

[3] Univ Manchester, Sch Biol Sci, Manchester, Lancs, England

来源：

MEDICAL MYCOLOGY | 2004年 / 42卷 / 01期

关键词：

D O I：

10.1080/13693780310001610029

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Extracellular phospholipase production by environmental and clinical isolates of Aspergillus fumigatus collected from several centres world-wide were compared. All isolates produced extracellular phospholipases which included phospholipase C and a phospholipid acyl hydrolase (phospholipase A and/or phospholipase B) activity. Clinical isolates of A. fumigatus produced the largest zone sizes in a diffusion assay and clinical isolates produced more extracellular phospholipase C than environmental isolates. However, environmental isolates of A. fumigatus showed increased acyl hydrolase activity compared to clinical isolates of A. fumigatus. This study suggests that extracellular phospholipase C activity, but not extracellular acyl hydrolase activity may be important in the pathogenicity of A. fumigatus.

引用

页码：81 / 86

页数：6

共 51 条

[1] ASPERGILLUS-FUMIGATUS ALLERGEN-I, A MAJOR IGE-BINDING PROTEIN, IS A MEMBER OF THE MITOGILLIN FAMILY OF CYTOTOXINS [J].