An Updated Review on Biologically Promising Natural Oxepines

被引：4
作者：
Mandal, Bhagirath [1 ]
Karmakar, Indrajit [1 ]
Brahmachari, Goutam [1 ]
机构：
[1] Visva Bharati, Dept Chem, Lab Nat Prod & Organ Synth, Santini Ketan 731235, W Bengal, India
来源：
CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 10期
关键词：
benzo-oxepines; dibenzo-oxepines; secondary metabolites; natural occurrence; biosynthesis; biological profiles; FARNESYL-PROTEIN TRANSFERASE; MARINE-DERIVED FUNGUS; ENDOPHYTIC FUNGUS; ANTIINFLAMMATORY CONSTITUENTS; ALKALOIDS; ANTIMYCOBACTERIAL; POLYKETIDES; DERIVATIVES; CULARINE; FUSIDIENOL;
D O I：
10.1002/cbdv.202200484
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Benzo-oxepines and dibenzo-oxepines, a unique class of naturally occurring secondary metabolites, are distributed mainly in plants and fungi and have received much attention from phytochemists and biologists based on their fascinating structural features and health-promoting functions. This review summarizes 100 oxepine derivatives comprising three categories: benzo-oxepine, dibenzo-oxepine, and pyrano-oxepine. Studies on various structural features and pharmacological activities of oxepine derivatives promote further in-depth research on these potent natural products. This review portrays the natural occurrence, bioactivity and biosynthesis of oxepines reported from 1984 to 2021.
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页数：14
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