Synthesis of poly-O-sulfated glycosides of 2,5-anhydro-D-mannitol

被引：7
|
作者：
Kuszmann, J [1 ]
Medgyes, G [1 ]
Boros, S [1 ]
机构：
[1] IVAX Drug Res Inst, H-1325 Budapest, Hungary
来源：
CARBOHYDRATE RESEARCH | 2005年 / 340卷 / 10期
关键词：
2.5-anhydro-D-mannitol derivatives; mono-; di-; tri-; tetra- and pentasaccharides; poly-O-sulfated saccharides; antiasthmatic compounds;
D O I：
10.1016/j.carres.2005.05.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
2,5-Anhydro-3-O-beta-D-glucopyranosyl-; -3-O-alpha-D-idopyranosyl-; -3-O-alpha-D-arabinopyranosyl-; -3-O-alpha-L-arabinopyranosyl--; -3-0-beta-D-maltopyranosyl-; -3-O-beta-D-gentiobiopyranosyl-; -1,6-di-O-beta-D-glucopyranosyl-; -1,6-di-O-alpha-L-idopyranosyl,-; -1-O-beta-D-maltopyranosyl-.- -1,3,.6-tri-O-beta-D-glucopyranosyl-; -1,6-di-O-beta-maltopyranosyl- and -1,6-di-O-beta-D-gentiobiopyranosyl-2,5-anhydro-D-mannitol as well as their poly-O-sulfated derivatives were synthesized. The IP3-IC50 values of their sodium and/or potassium salts were determined for structure-activity studies aiming at the synthesis of new, orally active antiasthmatic compounds. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1739 / 1749
页数：11
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