Recent Advancements in the Development of Anti-Breast Cancer Synthetic Small Molecules

被引：12
作者：
Elkaeed, Eslam B. [1 ]
Abd El Salam, Hayam A. [2 ]
Sabt, Ahmed [3 ]
Al-Ansary, Ghada H. [4 ]
Eldehna, Wagdy M. [5 ]
机构：
[1] AlMaarefa Univ, Coll Pharm, Dept Pharmaceut Sci, Riyadh 13713, Saudi Arabia
[2] Natl Res Ctr, Dept Green Chem, Cairo 12622, Egypt
[3] Natl Res Ctr, Chem Nat Cpds Dept, Cairo 12622, Egypt
[4] Ain Shams Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo 11566, Egypt
[5] Kafrelsheikh Univ, Fac Pharm, Dept Pharmaceut Chem, Kafrelsheikh 33516, Egypt
来源：
MOLECULES | 2021年 / 26卷 / 24期
关键词：
breast cancer therapy; organic synthesis; chemical scaffold; mechanistic insights; human malignancies; VITRO ANTIPROLIFERATIVE ACTIVITY; EMERGING TARGETED THERAPIES; TYROSINE KINASE INHIBITOR; BIOLOGICAL EVALUATION; QUINAZOLIN-4-ONE DERIVATIVES; SELECTIVE INHIBITORS; FERROCENYL COMPOUNDS; CYTOTOXIC ACTIVITY; DESIGN; POTENT;
D O I：
10.3390/molecules26247611
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Among all cancer types, breast cancer (BC) still stands as one of the most serious diseases responsible for a large number of cancer-associated deaths among women worldwide, and diagnosed cases are increasing year by year worldwide. For a very long time, hormonal therapy, surgery, chemotherapy, and radiotherapy were used for breast cancer treatment. However, these treatment approaches are becoming progressively futile because of multidrug resistance and serious side effects. Consequently, there is a pressing demand to develop more efficient and safer agents that can fight breast cancer belligerence and inhibit cancer cell proliferation, invasion and metastasis. Currently, there is an avalanche of newly designed and synthesized molecular entities targeting multiple types of breast cancer. This review highlights several important synthesized compounds with promising anti-BC activity that are categorized according to their chemical structures.
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页数：31
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