Tick-borne encephalitis: Pathogenesis and clinical implications

被引:113
作者
Ruzek, Daniel [1 ]
Dobler, Gerhard [2 ]
Mantke, Oliver Donoso [3 ]
机构
[1] Acad Sci Czech Republ, Inst Parasitol, Ctr Biol, CZ-37005 Ceske Budejovice, Czech Republic
[2] Bundeswehr Inst Microbiol, D-80937 Munich, Germany
[3] Robert Koch Inst, German Consultant Lab Tick Borne Encephalitis, D-13353 Berlin, Germany
关键词
Tick-borne encephalitis; Tick-borne encephalitis virus; Pathogenesis; Clinical data; REGIONAL LYMPHATIC-SYSTEM; CEREBROSPINAL-FLUID; VIRUS; INFECTION; MOUSE; FLAVIVIRUS; STRAIN; IMMUNOPATHOLOGY; EPIDEMIOLOGY; PENETRATION;
D O I
10.1016/j.tmaid.2010.06.004
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Tick-borne encephalitis (TBE) is an important and severe neurological illness occurring in large areas of Europe and northern Asia. Only a small proportion of those infected develop clinical symptoms. The symptomatic cases are, however, characterized with fevers and debilitating encephalitis that might progress into chronic disease or fatal infections. This review summarizes data on clinical presentation, pathogenesis and pathology of TBE in humans, and of experimental TBE in animal models with the purpose to explain why is TBE such a severe disease clinically. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:223 / 232
页数:10
相关论文
共 98 条
[1]   Tick-Borne Encephalitis Virus Infection of Cultured Mouse Macrophages [J].
Ahantarig, Arunee ;
Ruzek, Daniel ;
Vancova, Marie ;
Janowitz, Anna ;
Stastna, Hana ;
Tesarova, Martina ;
Grubhoffer, Libor .
INTERVIROLOGY, 2009, 52 (05) :283-290
[2]  
ALBRECHT P, 1960, Acta Virol, V4, P150
[3]  
Albrecht P, 1968, Curr Top Microbiol Immunol, V43, P44
[4]  
Albrecht P., 1962, BIOLOGY VIRUSES TICK, P247
[5]  
[Anonymous], COCHRANE DATABASE SY
[6]  
Arnez M, 2009, EXPERT REV ANTI-INFE, V7, P1251, DOI [10.1586/eri.09.99, 10.1586/ERI.09.99]
[7]   Changes in immune parameters and their correction in human cases of tick-borne encephalitis [J].
Atrasheuskaya, AV ;
Fredeking, IM ;
Ignatyev, GM .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2003, 131 (01) :148-154
[8]   Tick-borne encephalitis outbreak in Hungary due to consumption of raw goat milk [J].
Balogh, Zsuzsanna ;
Ferenczi, Emoke ;
Szeles, Klara ;
Stefanoff, Pawel ;
Gut, Wlodzimierz ;
Szomor, Katalin N. ;
Takacs, Maria ;
Berencsi, Gyorgy .
JOURNAL OF VIROLOGICAL METHODS, 2010, 163 (02) :481-485
[9]   Detection of anterior horn lesions by MRI in central European tick-borne encephalomyelitis [J].
Beer, S ;
Brune, N ;
Kesselring, J .
JOURNAL OF NEUROLOGY, 1999, 246 (12) :1169-1171
[10]   Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist [J].
Best, SM ;
Morris, KL ;
Shannon, JG ;
Robertson, SJ ;
Mitzel, DN ;
Park, GS ;
Boer, E ;
Wolfinbarger, JB ;
Bloom, ME .
JOURNAL OF VIROLOGY, 2005, 79 (20) :12828-12839