Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics

被引:18
作者
Niu, Guoqing [1 ,2 ]
Zheng, Jiazhen [1 ,3 ]
Tan, Huarong [1 ,3 ]
机构
[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100101, Peoples R China
[2] Southwest Univ, Biotechnol Res Ctr, Chongqing 400716, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
基金
中国国家自然科学基金;
关键词
nucleoside antibiotics; biosynthesis; combinatorial biosynthesis; STREPTOMYCES-TENDAE TU901; INDUSTRIAL POLYOXIN PRODUCER; CO-TRANSCRIBED GENES; NIKKOMYCIN BIOSYNTHESIS; BLASTICIDIN-S; MOLECULAR CHARACTERIZATION; HETEROLOGOUS EXPRESSION; MILDIOMYCIN BIOSYNTHESIS; PIRICULARIA ORYZAE; PEPTIDYL MOIETY;
D O I
10.1007/s11427-017-9116-0
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
There is an urgent need for new antifungal agents to treat or combat fungal infection in humans and plants. Antifungal nucleoside antibiotics are an important family of natural products with distinctive structural features. Understanding their biosynthetic machinery is of great importance for the improvement of antibiotics titers. More importantly, it is a requisite for combinatorial biosynthesis to create hybrid nucleoside antibiotics. We herein focus on findings on the natural and designed biosynthesis of this important family of nucleoside antibiotics.
引用
收藏
页码:939 / 947
页数:9
相关论文
共 70 条
[1]   Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis [J].
Binter, Alexandra ;
Oberdorfer, Gustav ;
Hofzumahaus, Sebastian ;
Nerstheimer, Stefanie ;
Altenbacher, Georg ;
Gruber, Karl ;
Macheroux, Peter .
FEBS JOURNAL, 2011, 278 (21) :4122-4135
[2]   Production of nikkomycins Bx and Bz by mutasynthesis with genetically engineered Streptomyces tendae TU901 [J].
Bormann, C ;
Kálmánczhelyi, A ;
Süssmuth, R ;
Jung, G .
JOURNAL OF ANTIBIOTICS, 1999, 52 (02) :102-108
[3]   Nikkomycin biosynthesis: Formation of a 4-electron oxidation product during turnover of NikD with its physiological substrate [J].
Bruckner, RC ;
Zhao, GH ;
Venci, D ;
Jorns, MS .
BIOCHEMISTRY, 2004, 43 (28) :9160-9167
[4]  
Bruntner C, 1999, MOL GEN GENET, V262, P102
[5]   The Streptomyces tendae Tu901 L-lysine 2-aminotransferase catalyzes the initial reaction in nikkomycin D biosynthesis [J].
Bruntner, C ;
Bormann, C .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 254 (02) :347-355
[6]   Building biological foundries for next-generation synthetic biology [J].
Chao Ran ;
Yuan YongBo ;
Zhao HuiMin .
SCIENCE CHINA-LIFE SCIENCES, 2015, 58 (07) :658-665
[7]  
Chaudhary PM, 2013, MINI-REV MED CHEM, V13, P222
[8]   Formation of β-hydroxy histidine in the biosynthesis of nikkomycin antibiotics [J].
Chen, H ;
Hubbard, BK ;
O'Connor, SE ;
Walsh, CT .
CHEMISTRY & BIOLOGY, 2002, 9 (01) :103-112
[9]   Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the "pathway redundancy" in metabolic networks [J].
Chen, Wenqing ;
Dai, Daofeng ;
Wang, Changchun ;
Huang, Tingting ;
Zhai, Lipeng ;
Deng, Zixin .
MICROBIAL CELL FACTORIES, 2013, 12
[10]   Characterization of the Polyoxin Biosynthetic Gene Cluster from Streptomyces cacaoi and Engineered Production of Polyoxin H [J].
Chen, Wenqing ;
Huang, Tingting ;
He, Xinyi ;
Meng, Qingqing ;
You, Delin ;
Bai, Linquan ;
Li, Jialiang ;
Wu, Mingxuan ;
Li, Rui ;
Xie, Zhoujie ;
Zhou, Huchen ;
Zhou, Xiufen ;
Tan, Huarong ;
Deng, Zixin .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (16) :10627-10638