The synthesis of RNA containing the modified nucleotides N2-methylguanosine and N6,N6-dimethyladenosine

被引：7
|
作者：
Rife, JP
Cheng, CS
Moore, PB
Strobel, SA [1 ]
机构：
[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA
[2] Yale Univ, Dept Biochem & Mol Biophys, New Haven, CT 06520 USA
来源：
NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 12期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
D O I：
10.1080/07328319808004317
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The phosphoramidites of the naturally occurring modified nucleotides N-2-methylguanosine and N-6,N-6-dimethyladenosine were synthesized and incorporated into short oligoribonucleotides. Described are the syntheses of the phosphoramidites and the procedures used to deprotect oligoribonucleotides in which the O-6 Of m(2)G is protected with a 2-(p-nitrophenyl)ethyl group.
引用
收藏
页码：2281 / 2288
页数：8
相关论文
共 50 条
  • [41] The crystal structure of N6,N6′-di(pyridin-2-yl)-[2,2′-bipyridine]-6,6′-diamine, C20H16N6
    Sun, Yue
    Yang, Tianyu
    Wang, Wenxiang
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2022, 237 (01): : 9 - 11
  • [42] Eder 'Symphony N6'
    Kramer, G
    OSTERREICHISCHE MUSIK ZEITSCHRIFT, 1998, 53 (05): : 77 - 77
  • [43] Identifying RNA minor groove tertiary contracts by nucleotide analogue interference mapping with N2-methylguanosine
    Biochem, 37 (12933):
  • [44] Identifying RNA minor groove tertiary contacts by nucleotide analogue interference mapping with N2-methylguanosine
    Ortoleva-Donnelly, L
    Kronman, M
    Strobel, SA
    BIOCHEMISTRY, 1998, 37 (37) : 12933 - 12942
  • [45] 16S RIBOSOMAL-RNA OF ESCHERICHIA-COLI CONTAINS A N2-METHYLGUANOSINE AT 27 NUCLEOTIDES FROM THE 3' END
    VANCHARLDORP, R
    HEUS, HA
    VANKNIPPENBERG, PH
    NUCLEIC ACIDS RESEARCH, 1981, 9 (12) : 2717 - 2725
  • [46] Vibrational fingerprints of N6-methyladenine and N6,N6-dimethyladenine in Raman spectra
    Dinh Bao Nguyen
    Thanh Danh Nguyen
    Kim, Sangsoo
    Joo, Sang-Woo
    VIBRATIONAL SPECTROSCOPY, 2017, 90 : 7 - 13
  • [47] Synthesis of N6,N6-Dialkyladenine Nucleosides Using Hexaalkylphosphorus Triamides Produced in Situ
    Lakshman, Mahesh K.
    Choudhury, Asad
    Bae, Suyeal
    Rochttis, Eliezer
    Pradhan, Padmanava
    Kumar, Amit
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2009, 2009 (01) : 152 - 159
  • [48] DLm6Am: A Deep-Learning-Based Tool for Identifying N6,2′-O-Dimethyladenosine Sites in RNA Sequences
    Luo, Zhengtao
    Su, Wei
    Lou, Liliang
    Qiu, Wangren
    Xiao, Xuan
    Xu, Zhaochun
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (19)
  • [49] METHYL-DEFICIENT MAMMALIAN 4S RNA - EVIDENCE FOR L-ETHIONINE-INDUCED INHIBITION OF N6-DIMETHYLADENOSINE SYNTHESIS IN RAT-LIVER TRANSFER-RNA
    WILDENAUER, D
    GROSS, HJ
    NUCLEIC ACIDS RESEARCH, 1974, 1 (02) : 279 - 288
  • [50] Theoretical exploration of polynitrogen compounds N6, N8, N10, and N6 ions based on N3- and cyclo-N5-
    Jiang, Shuaijie
    Lang, Qing
    Xu, Yuangang
    Lin, Qiuhan
    Wang, Pengcheng
    Lu, Ming
    JOURNAL OF ENERGETIC MATERIALS, 2025, 43 (01) : 97 - 115
12345