The synthesis of RNA containing the modified nucleotides N2-methylguanosine and N6,N6-dimethyladenosine

被引：7
|
作者：
Rife, JP
Cheng, CS
Moore, PB
Strobel, SA [1 ]
机构：
[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA
[2] Yale Univ, Dept Biochem & Mol Biophys, New Haven, CT 06520 USA
来源：
NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 12期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
D O I：
10.1080/07328319808004317
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The phosphoramidites of the naturally occurring modified nucleotides N-2-methylguanosine and N-6,N-6-dimethyladenosine were synthesized and incorporated into short oligoribonucleotides. Described are the syntheses of the phosphoramidites and the procedures used to deprotect oligoribonucleotides in which the O-6 Of m(2)G is protected with a 2-(p-nitrophenyl)ethyl group.
引用
收藏
页码：2281 / 2288
页数：8
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