Atrial cardiomyocyte calcium signalling

被引:76
作者
Bootman, Martin D. [1 ]
Smyrnias, Ioannis [1 ]
Thul, Ruediger [2 ]
Coombes, Stephen [2 ]
Roderick, H. Llewelyn [1 ,3 ]
机构
[1] Babraham Inst, Mol Signalling Lab, Cambridge CB22 3AT, England
[2] Univ Nottingham, Dept Math Sci, Nottingham NG7 2RD, England
[3] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2011年 / 1813卷 / 05期
基金
英国生物技术与生命科学研究理事会;
关键词
Cardiac; Calcium; Arrhythmia; Signalling; Atrial; Ryanodine; Inositol; Inotropy; Excitation-contraction coupling; T-tubules; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; RAT VENTRICULAR MYOCYTES; INDUCED HEART-FAILURE; CA2+ RELEASE UNITS; SARCOPLASMIC-RETICULUM; CARDIAC MYOCYTES; TRANSVERSE TUBULES; RYANODINE RECEPTORS; PURKINJE-CELLS; T-TUBULES;
D O I
10.1016/j.bbamcr.2011.01.030
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Whereas Ca(2+) signalling in ventricular cardiomyocytes is well described, much less is known regarding the Ca(2+) signals within atrial cells. This is surprising given that atrial cardiomyocytes make an important contribution to the refilling of ventricles with blood, which enhances the subsequent ejection of blood from the heart. The dependence of cardiac function on the contribution of atria becomes increasingly important with age and exercise. Disruption of the rhythmic beating of atrial cardiomyocytes can lead to life-threatening conditions such as atrial fibrillation. Atrial and ventricular myocytes have many structural and functional similarities. However, one key structural difference, the lack of transverse tubules ("T-tubules") in atrial myocytes, make these two cell types display vastly different calcium patterns in response to electrical excitation. The lack of T-tubules in atrial myocytes means that depolarisation provokes calcium signals that originate around the periphery of the cells. Under resting conditions, such Ca(2+) signals do not propagate towards the centre of the atrial cells and so do not fully engage the contractile machinery. Consequently, contraction of atrial myocytes under resting conditions is modest. However, when atrial myocytes are stimulated with a positive inotropic agonist, such as isoproterenol, the peripheral Ca(2+) signals trigger a global wave of Ca(2+) that propagates in a centripetal manner into the cells. Enhanced centripetal movement of Ca(2+) in atrial myocytes leads to increased contraction and a more substantial contribution to blood pumping. This article is part of a Special Issue entitled: 11th European Symposium on Calcium. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:922 / 934
页数:13
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