PEComa: Another member of the MiT tumor family?

被引：54

作者：

Righi, Alberto ^{[1
]}

Dimosthenous, Kypros ^{[1
]}

Rosai, Juan ^{[1
]}

机构：

[1] Univ Bologna, Bellaria Hosp, Ctr Diagnost Italiano Milan & Anat Pathol, I-40139 Bologna, Italy

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2008年 / 16卷 / 01期

关键词：

PEComa; MiT tumor family; malignant tumor;

D O I：

10.1177/1066896907309733

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We report 2 cases of PEComa, one occurring in the colon of an I I-year-old boy and the other in the bone (fibula) of a 92-year-old woman. Both tumors consisted of nests of large epithelioid cells surrounded by a fibrovascular stroma. The nuclei were large and vesicular, with prominent centrally located nucleoli. The cytoplasm was eosinophilic, with a fine to coarse granularity. Mitoses and individual cell necrosis were infrequent. Immunohistochemically, both tumors showed strong cytoplasmic expression of HMB-45 and intense nuclear positivity for TFE3. To our knowledge, nuclear positivity for TFE3 has been previously reported in only 5 cases of PEComa. Reactivity to this marker suggests that PEComa should be added to the growing list of human tumors of the so-called MiT family gene.

引用

页码：16 / 20

页数：5

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