Mechanics of hydrogel-based bioprinting: From 3D to 4D

被引:15
作者
Yang, Qingzhen [1 ,2 ,3 ,4 ]
Lv, Xuemeng [1 ,2 ]
Gao, Bin [5 ]
Ji, Yuan [1 ,2 ]
Xu, Feng [1 ,2 ]
机构
[1] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr BEBC, Xian, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, Micro Nanotechnol Res Ctr, State Key Lab Mfg Syst Engn, Xian, Shaanxi, Peoples R China
[4] Xi An Jiao Tong Univ, Res Inst, Hangzhou, Zhejiang, Peoples R China
[5] Air Force Mil Med Univ, Tangdu Hosp, Dept Endocrinol, Xian, Shaanxi, Peoples R China
来源
ADVANCES IN APPLIED MECHANICS, VOL 54 | 2021年 / 54卷
基金
中国国家自然科学基金;
关键词
VISCOUS-LIQUID; BIOMIMETIC MATERIALS; SHEAR-STRESS; TISSUE; DROPLET; DYNAMICS; BREAKUP; FABRICATION; POLYMER; SURFACE;
D O I
10.1016/bs.aams.2021.03.001
中图分类号
TH [机械、仪表工业];
学科分类号
0802 ;
摘要
Bioprinting has emerged as a powerful technique with widespread applications in biomedical engineering and other fields. In bioprinting, programmable patterns are enabled by ejecting hydrogels with/without cells from the nozzle and eventually 3D complex constructs can be obtained in a layer-by-layer manner. Subsequently, the hydrogels are crosslinked into solid state by physical or chemical methods. Recently, 3D bioprinting has been extended to 4D bioprinting where "time" as the fourth dimension is incorporated. In 4D bioprinting, the printed bioconstructs can change their shapes or functionalities when imposing an external stimulus. For 3D/4D bioprinting, some physical phenomena (e.g., formation of droplets/filaments, droplets impact upon the substrate, self-deformation triggered by stimuli) are closely related to mechanics, which will affect the printing resolution and fidelity of printed bioconstructs. Besides, cells are sensitive to mechanical cues, i.e., the mechanical microenvironment that cells experience during and post printing has significant effects on cells behaviors and functionalities. Understanding the mechanics in bioprinting is thus of great importance. In this paper, we summarize the physics of bioprinting from the viewpoint of solid and fluid mechanics. Lights are shed on the droplets/filaments formation, droplets impact upon the receiving surface, and the mechanical microenvironment that cells experience during and post printing. By analyzing the mechanics of bioprinting, this review could be of help in understanding the bioprinting mechanism and predicting the future direction.
引用
收藏
页码:285 / 318
页数:34
相关论文
共 172 条
[11]   Biodegradable Elastomers for Tissue Engineering and Cell-Biomaterial Interactions [J].
Bettinger, Christopher J. .
MACROMOLECULAR BIOSCIENCE, 2011, 11 (04) :467-482
[12]   Formation of beads-on-a-string structures during break-up of viscoelastic filaments [J].
Bhat, Pradeep P. ;
Appathurai, Santosh ;
Harris, Michael T. ;
Pasquali, Matteo ;
McKinley, Gareth H. ;
Basaran, Osman A. .
NATURE PHYSICS, 2010, 6 (08) :625-631
[13]  
Blaeser A, 2015, TISSUE ENG PT A, V21, pS322
[14]   Controlling Shear Stress in 3D Bioprinting is a Key Factor to Balance Printing Resolution and Stem Cell Integrity [J].
Blaeser, Andreas ;
Campos, Daniela Filipa Duarte ;
Puster, Uta ;
Richtering, Walter ;
Stevens, Molly M. ;
Fischer, Horst .
ADVANCED HEALTHCARE MATERIALS, 2016, 5 (03) :326-333
[15]   Self-Folding Thermo-Magnetically Responsive Soft Microgrippers [J].
Breger, Joyce C. ;
Yoon, ChangKyu ;
Xiao, Rui ;
Kwag, Hye Rin ;
Wang, Martha O. ;
Fisher, John P. ;
Nguyen, Thao D. ;
Gracias, David H. .
ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (05) :3398-3405
[16]   ITERATED INSTABILITIES DURING DROPLET FISSION [J].
BRENNER, MP ;
SHI, XD ;
NAGEL, SR .
PHYSICAL REVIEW LETTERS, 1994, 73 (25) :3391-3394
[17]   Multiscale modeling of material failure: Theory and computational methods [J].
Budarapu, Pattabhi Ramaiah ;
Zhuang, Xiaoying ;
Rabczuk, Timon ;
Bordas, Stephane P. A. .
ADVANCES IN CRYSTALS AND ELASTIC METAMATERIALS, PT 2, 2019, 52 :1-103
[18]   Modeling the splash of a droplet impacting a solid surface [J].
Bussmann, M ;
Chandra, S ;
Mostaghimi, J .
PHYSICS OF FLUIDS, 2000, 12 (12) :3121-3132
[19]   Current developments in multifunctional smart materials for 3D/4D bioprinting [J].
Castro, Nathan J. ;
Meinert, Christoph ;
Levett, Peter ;
Hutmacher, Dietmar W. .
CURRENT OPINION IN BIOMEDICAL ENGINEERING, 2017, 2 :67-75
[20]  
Chandrasekhar S., 2013, HYDRODYNAMIC HYDROMA