ANALYSIS OF SERUM CYSTATIN C LEVELS IN HEALTHY INDIVIDUALS IN NANCHONG (SICHUAN PROVINCE, CHINA)

Objective: The aim of the present study was to investigate the distribution and abnormal detection rate of serum cystatin C (CysC) levels in healthy individuals in Nanchong (Sichuan Province, China). Methods: A group of healthy individuals undergoing physical examinations at a tertiary A hospital in Nanchong City from January to August 2018 was studied to compare serum CysC levels and their abnormal detection rates as a function of age, sex, blood pressure, blood glucose, blood lipids, and body mass index (BMI). Results: Serum CysC levels and their abnormal detection rate in healthy individuals were 0.79 +/- 0.25 mg/L and 8.5%, respectively, which gradually increased with age. At different ages, the abnormal detection rate was significantly higher in males than in females (P<0.05). For individuals under 60 years old, serum CysC levels were higher in males than in females (P<0.05). Individuals who were overweight or obese, had high blood pressure, or had abnormal blood lipids had higher serum CysC levels and abnormal detection rates than those with normal or low BMIs, normal or low blood pressure, or normal blood lipids, respectively (P<0.05). Conclusions: Serum CysC levels and abnormal detection rates were high in our Nanchong cohort. Hence, public health departments should strengthen the prevention and treatment of chronic kidney disease, especially in individuals who are overweight/obese or have high blood pressure, abnormal blood lipids, or high blood glucose.