Stent Thrombogenicity Early in High-Risk Interventional Settings Is Driven by Stent Design and Deployment and Protected by Polymer-Drug Coatings

被引:652
作者
Kolandaivelu, Kumaran [1 ,2 ]
Swaminathan, Rajesh [1 ]
Gibson, William J. [1 ]
Kolachalama, Vijaya B. [1 ]
Nguyen-Ehrenreich, Kim-Lien [3 ]
Giddings, Virginia L. [3 ]
Coleman, Leslie [3 ]
Wong, Gee K. [1 ,4 ]
Edelman, Elazer R. [1 ,2 ]
机构
[1] Harvard MIT Div Hlth Sci & Technol, Cambridge, MA USA
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc, Boston, MA 02115 USA
[3] Abbott Vasc, Santa Clara, CA USA
[4] Concord Biomed Sci & Emerging Technol, Lexington, MA USA
基金
美国国家卫生研究院;
关键词
hemodynamics; malapposition; overlapping stents; stents; thrombosis; CORONARY-ARTERY-DISEASE; INTRAVASCULAR ULTRASOUND GUIDANCE; BARE-METAL STENTS; ELUTING STENTS; THROMBOSIS; IMPLANTATION; RESTENOSIS; TRIAL; METAANALYSIS; ANTICOAGULATION;
D O I
10.1161/CIRCULATIONAHA.110.003210
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-Stent thrombosis is a lethal complication of endovascular intervention. Concern has been raised about the inherent risk associated with specific stent designs and drug-eluting coatings, yet clinical and animal support is equivocal. Methods and Results-We examined whether drug-eluting coatings are inherently thrombogenic and if the response to these materials was determined to a greater degree by stent design and deployment with custom-built stents. Drug/polymer coatings uniformly reduce rather than increase thrombogenicity relative to matched bare metal counterparts (0.65-fold; P=0.011). Thick-strutted (162 mu m) stents were 1.5-fold more thrombogenic than otherwise identical thin-strutted (81 mu m) devices in ex vivo flow loops (P<0.001), commensurate with 1.6-fold greater thrombus coverage 3 days after implantation in porcine coronary arteries (P=0.004). When bare metal stents were deployed in malapposed or overlapping configurations, thrombogenicity increased compared with apposed, length-matched controls (1.58-fold, P=0.001; and 2.32-fold, P<0.001). The thrombogenicity of polymer-coated stents with thin struts was lowest in all configurations and remained insensitive to incomplete deployment. Computational modeling-based predictions of stent-induced flow derangements correlated with spatial distribution of formed clots. Conclusions-Contrary to popular perception, drug/polymer coatings do not inherently increase acute stent clotting; they reduce thrombosis. However, strut dimensions and positioning relative to the vessel wall are critical factors in modulating stent thrombogenicity. Optimal stent geometries and surfaces, as demonstrated with thin stent struts, help reduce the potential for thrombosis despite complex stent configurations and variability in deployment. (Circulation. 2011;123:1400-1409.)
引用
收藏
页码:1400 / 1409
页数:10
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