Caveolin-1 Function in Liver Physiolocy and Disease

被引：73

作者：

Fernandez-Rojo, Manuel A. ^{[1
,2
]}

Ramm, Grant A. ^{[1
,2
]}

机构：

[1] Queensland Inst Med Res, Berghofer Med Res Inst, Brisbane, Qld, Australia

[2] Univ Queensland, Fac Med & Biomed Sci, Brisbane, Qld, Australia

来源：

TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 10期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

NITRIC-OXIDE SYNTHASE; CONGENITAL GENERALIZED LIPODYSTROPHY; HEPATOCARCINOMA CELL-LINES; LIPID-METABOLISM; PLASMA-MEMBRANE; HIGH-DENSITY; FREE-CHOLESTEROL; UP-REGULATION; MITOCHONDRIAL DYSFUNCTION; RAT HEPATOCYTES;

D O I：

10.1016/j.molmed.2016.08.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caveolin-1 (CAV1), the structural protein of caveolae in the plasma membrane, has emerged as a regulator of liver function. CAV1 modulates several molecular pathways leading to the regulation of hepatic lipid accumulation, lipid and glucose metabolism, mitochondria, biology, and hepatocyte proliferation. CAV1 thus plays a crucial role in maintaining hepatic physiology during metabolic adaptation to fasting, liver steatosis, and hepatocyte proliferation associated with liver regeneration. With failure of such processes, CAV1 has been implicated in the modulation of cholestasis, hepatitis, cirrhosis, and hepato-carcinogenesis. This review discusses the latest research in CAV1 biology and related proteins, aiming to guide future endeavors that explore their role in liver physiology and disease.

引用

收藏

页码：889 / 904

页数：16

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