Association Between Medication and Intestinal Intussusception in Children A Case-Crossover Study

被引:3
作者
Vega Garcia, Lourdes [1 ]
Fuentes-Leonarte, Virginia [2 ,3 ]
Maria Tenias, Jose [2 ,4 ]
Correcher Medina, Patricia [5 ]
Arias Arias, Angel [4 ]
Roman Ortiz, Carmen [4 ]
机构
[1] Valencian Sch Hlth Studies, Valencia, Spain
[2] Spanish Consortium Res Epidemiol & Publ Hlth, Barcelona, Spain
[3] Ctr Adv Res Publ Hlth, Valencia, Spain
[4] Hosp Gen La Mancha Ctr, Res Support Unit, Ciudad Real, Spain
[5] Hosp La Fe, Dept Pediat, Valencia, Spain
关键词
intussusception; antimicrobial agents; case-crossover study; ROTAVIRUS VACCINE; ANTIBIOTIC USE; RISK; ADENOVIRUS; PENTAVALENT; INFECTION; CHILDHOOD;
D O I
10.1097/PEC.0000000000000397
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objectives: This study aimed to assess the association between the appearance of intussusception in children andmedication intake in the immediately preceding period (2-15 days). Methods: A case-crossover design was used. We selected cases of children admitted with a diagnosis of intussusception (International Classification of Diseases, Ninth Revision, 860) to the major hospitals in the city of Valencia, Spain, from 2006 to 2009. We then estimated the association between the episode of intussusception and the intake of prescription medication during the preceding 2, 7, and 15 days (case period) and for the same timewindow1, 2, 3, and 4months prior (control period). Data on previous drug administration were obtained from the Pharmaceutical Service Manager System. Results: A total of 95 cases (65.3% boys and 34.7% girls) were selected; 76.6% were younger than the age of 2 years. The association between intussusception and prior drug use varied depending on the exposure window: 15-day odds ratio (OR), 1.45 (95% confidence interval [95% CI], 0.86-2.43); 7-day OR, 1.46 (95% CI, 0.80-2.67); and 2-day OR, 2.26 (95% CI, 1.10-4.64). These associations were greater for children aged younger than 2 years and were usually due to the recent administration (preceding 2 days) of antibiotics (OR, 8.00; 95% CI, 1.47-43.7). Conclusions: Intussusception was more common among boys aged younger than 2 years. A positive and significant association was observed when drugs were administered 2 to 7 days before the onset of symptoms in children younger than the age of 2 years.
引用
收藏
页码:250 / 254
页数:5
相关论文
共 26 条
  • [1] Real-Time Surveillance to Assess Risk of Intussusception and Other Adverse Events After Pentavalent, Bovine-Derived Rotavirus Vaccine
    Belongia, Edward A.
    Irving, Stephanie A.
    Shui, Irene M.
    Kulldorff, Martin
    Lewis, Edwin
    Yin, Ruihua
    Lieu, Tracy A.
    Weintraub, Eric
    Yih, W. Katherine
    Li, Rong
    Baggs, James
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2010, 29 (01) : 1 - 5
  • [2] Bines J, 2002, Acute Intussusception in Infants and Children: a Global Perspective. Vaccines and Biologicals
  • [3] Bines JE, 2005, CURR OPIN GASTROEN, V21, P20
  • [4] Clinical case definition for the diagnosis of acute intussusception
    Bines, JE
    Ivanoff, T
    Justice, F
    Mulholland, K
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2004, 39 (05) : 511 - 518
  • [5] Risk factors for intussusception in infants in Vietnam and Australia: Adenovirus implicated, but not rotavirus
    Bines, Julie E.
    Liem, Nguyen Thanh
    Justice, Frances A.
    Son, Tran Ngoc
    Kirkwood, Carl D.
    De Campo, Margaret
    Barnett, Peter
    Bishop, Ruth F.
    Robins-Browne, Roy
    Carlin, John B.
    [J]. JOURNAL OF PEDIATRICS, 2006, 149 (04) : 452 - 460
  • [6] EFFECTS OF AMOXICILLIN-CLAVULANATE COMBINATION ON THE MOTILITY OF THE SMALL-INTESTINE IN HUMAN-BEINGS
    CARON, F
    DUCROTTE, P
    LEREBOURS, E
    COLIN, R
    HUMBERT, G
    DENIS, P
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (06) : 1085 - 1088
  • [7] Cosme-Labarthe JE, 2006, MED SUR, V13, P64
  • [8] CRISPEN C, 1985, CLIN PEDIATR, V24, P140
  • [9] New hypothesis on the pathogenesis of ileocecal intussusception
    Cserni, Tamas
    Paran, Sri
    Puri, Prem
    [J]. JOURNAL OF PEDIATRIC SURGERY, 2007, 42 (09) : 1515 - 1519
  • [10] Intussusception in early childhood:: A cohort study of 1.7 million children
    Fischer, TK
    Bihrmann, K
    Perch, M
    Koch, A
    Wohlfahrt, J
    Kåre, M
    Melbye, M
    [J]. PEDIATRICS, 2004, 114 (03) : 782 - 785