New secondary metabolites from the endophytic fungus Fusarium sp HP-2 isolated from "Qi-Nan" agarwood

被引：18
|
作者：
Xiao, Wen-Jie [1 ]
Chen, Hui-Qin [1 ]
Wang, Hao [1 ]
Cai, Cai-Hong [1 ]
Mei, Wen-Li [1 ]
Dai, Hao-Fu [1 ]
机构：
[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China
来源：
FITOTERAPIA | 2018年 / 130卷
关键词：
Qi-Nan" agarwood; Endophytic fungus; Fusarium sp; Furan derivative; Naphthalenone derivative; AQUILARIA-SINENSIS; GENES;
D O I：
10.1016/j.fitote.2018.08.008
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel pyrone derivative (1) bearing two fused five-member rings, together with two new naphthalenone derivatives (2, 3), as well as two known compounds (4, 5) were obtained from the endophytic fungus Fusarium sp. HP-2, which was isolated from "Qi-Nan" agarwood. The structures of the new compounds were elucidated by analysis of 1D and 2D NMR, and by HRESIMS spectra, as well as by comparison with the literature. Bioactivity results indicated that compound 3 showed weak acetylcholinesterase inhibitory activity.
引用
收藏
页码：180 / 183
页数：4
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