Controversy in the Allometric Application of Fixed- Versus Varying-Exponent Models: A Statistical and Mathematical Perspective

被引：10

作者：

Tang, Huadong ^{[1
]}

Hussain, Azher ^{[2
]}

Leal, Mauricio ^{[3
]}

Fluhler, Eric ^{[4
]}

Mayersohn, Michael ^{[5
]}

机构：

[1] Merck Res Lab, Drug Metab & Pharmacokinet, Kenilworth, NJ 07033 USA

[2] Merck Res Lab, Drug Metab & Pharmacokinet, West Point, PA 19486 USA

[3] Wyeth Ayerst Res, Drug Safety & Metab, Pearl River, NY 10965 USA

[4] Wyeth Res, Drug Safety & Metab, Groton, CT 06340 USA

[5] Univ Arizona, Coll Pharm, Dept Pharmaceut Sci, Tucson, AZ 85721 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2011年 / 100卷 / 02期

关键词：

Allometry; clearance; PK predictions; fixed-exponent allometry; varying-exponent allometry; HUMAN DRUG CLEARANCE; PHARMACOKINETIC PARAMETERS; IN-VITRO; PREDICTION; HUMANS; FUNCTIONALITY; ACCURACY; METABOLISM; RAT;

D O I：

10.1002/jps.22316

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This commentary is a reply to a recent article by Mahmood commenting on the authors' article on the use of fixed-exponent allometry in predicting human clearance. The commentary discusses eight issues that are related to criticisms made in Mahmood's article and examines the controversies (fixed-exponent vs. varying-exponent allometry) from the perspective of statistics and mathematics. The key conclusion is that any allometric method, which is to establish a power function based on a limited number of animal species and to extrapolate the resulting power function to human values (varying-exponent allometry), is infused with fundamental statistical errors. (C) 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:402-410, 2011

引用

页码：402 / 410

页数：9